{
  "abstract": "We herein report a rare case of non-IgM lymphoplasmacytic lymphoma (LPL) and acute myeloid leukemia (AML). A 64-year-old man with MYD88 L252P-positive LPL developed inv(16)-positive AML during LPL follow-up. Chemotherapy eradicated both AML and LPL cells from the bone marrow. Whole-exome sequencing revealed distinct mutation profiles with no shared mutations between the LPL and AML clones. These data suggest the coincidental development of genetically independent clones rather than a common ancestral origin. Our findings indicate the need for genomic stratification in dual hematological malignancies to accurately distinguish between coincidental and clonally related diseases.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Kodama Shimanaka"
    },
    {
      "name": "Tatsuhiro Sakamoto"
    },
    {
      "name": "Kenichi Makishima"
    },
    {
      "name": "Fumiaki Matsumura"
    },
    {
      "name": "Sakurako Suma"
    },
    {
      "name": "Yuya Sasaki"
    },
    {
      "name": "Yasuhito Suehara"
    },
    {
      "name": "Takayasu Kato"
    },
    {
      "name": "Keiichiro Hattori"
    },
    {
      "name": "Naoki Kurita"
    },
    {
      "name": "Hidekazu Nishikii"
    },
    {
      "name": "Naoshi Obara"
    },
    {
      "name": "Mamiko Sakata-Yanagimoto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ff5tbjpqfxjk4.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7759-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7759-26/_article",
  "id": "ff5tbjpqfxjk4",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7759-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7214618942",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7759-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ff5tbjpqfxjk4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7759-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7759-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Acute Myeloid Leukemia Research",
      "subfield": "general"
    }
  ],
  "title": "Coexistence of Clonally Unrelated Acute Myeloid Leukemia Harboring CBFB::MYH11 and Lymphoplasmacytic Lymphoma Harboring MYD88 L252P Mutation",
  "title_text": "Coexistence of Clonally Unrelated Acute Myeloid Leukemia Harboring CBFB::MYH11 and Lymphoplasmacytic Lymphoma Harboring MYD88 L252P Mutation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/ff5tbjpqfxjk4",
  "venue": "Internal Medicine",
  "versions": []
}