{
  "abstract": "Human brain assembloids provide a tractable platform for studying mutation-specific network dysfunction, but most studies do not distinguish whether abnormal activity arises from increased spontaneous initiation or stronger history-dependent amplification. We introduce a low-dimensional discrete-time self-exciting population model for calcium-imaging event sequences that separates baseline initiation (%[mu]), integrated history-dependent gain (%[eta]), and memory decay (%[tau]). Across 175 recordings from 13 MAPT p.R406W or CRISPR-corrected isogenic assembloids, biological-unit inference identified a 4.31-fold increase in %[eta] in mutants (95% CI 3.20- 5.84; exact p=7.8x10-4), without increased baseline activity. Parametric predictive checks exposed residual Poisson overdispersion; fixed-decay and beta-binomial sensitivity analyses nevertheless preserved the mutant history effect. Median %[eta] separated all 13 held-out assembloids, while a multifeature recording-level RBF-SVM achieved AUC 0.816 under nested whole-assembloid holdout. These results identify robust history-dependent temporal amplification as a functional MAPT-mutant network phenotype.",
  "abstract_shown": true,
  "affiliations": [
    "Carnegie Mellon University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "T. Monsoor"
    },
    {
      "name": "C. M. McCrimmon"
    },
    {
      "affs": [
        0
      ],
      "name": "P. Sinha"
    },
    {
      "name": "L. Zhang"
    },
    {
      "name": "M. R. Dareddy"
    },
    {
      "name": "M. E. Lorasdagi"
    },
    {
      "name": "R. A. Samarasinghe"
    },
    {
      "name": "V. Roychowdhury"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ffjrnadtvjad5.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.01.756068",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.01.756068v1.full",
  "id": "ffjrnadtvjad5",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.01.756068v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2805|Neural dynamics and brain function"
    ]
  ],
  "openalex": "W7220916145",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.01.756068v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ffjrnadtvjad5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:40Z",
      "native_id": "10.64898/2026.10.01.756068",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.01.756068v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Self-Exciting Population Event Models Reveal Abnormal Temporal Amplification in MAPT-Mutant Human Brain Assembloids",
  "title_text": "Self-Exciting Population Event Models Reveal Abnormal Temporal Amplification in MAPT-Mutant Human Brain Assembloids",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:40Z",
  "url": "https://research.draconitic.com/paper/ffjrnadtvjad5",
  "venue": "bioRxiv",
  "versions": []
}