{
  "abstract": "BV-AVD (brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine) has improved outcomes in advanced-stage Hodgkin lymphoma (ASHL); however, toxicity such as peripheral neuropathy (PN) remains a concern. Previous studies in oncology have demonstrated an association between sarcopenia and chemotoxicity. Therefore, we examined the effects of body composition parameters, including skeletal muscle (SM), subcutaneous fat (SF), and visceral fat (VF), along with quantitative biomarkers including metabolic tumor volume (MTV), on PN, treatment response, and progression-free survival. This study retrospectively reviewed the baseline, interim, and end-of-treatment (EOT) positron emission tomography-computed tomography (PET-CT) for 39 patients with ASHL treated with BV-AVD and assessed changes in MTV and body composition. MTV declined significantly from baseline to interim PET and EOT PET-CT (EOT PET), with no significant difference between the latter time points, indicating an early treatment response. SM:VF and SF:VF ratios followed a similar pattern, suggesting that changes in body composition including SM loss (sarcopenia) and changes in fat distribution (SF:VF), occurred early during treatment. Patients with stable SM:VF ratios were more likely to achieve a complete response (CR), whereas larger changes in SM:VF and SF:VF ratios and an early increase in VF were associated with failure to achieve CR, possibly due to increased inflammation. Stage IV disease and higher MTV were both associated with increased PN and may reflect the wider distribution of BV and an amplified inflammatory response. These findings demonstrate that body composition and PET-CT indices are relevant biomarkers in ASHL, and their integration with MTV may enhance risk stratification and deepen our understanding of toxicity risk.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL",
    "Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL",
    "Department of Biostatistics, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL",
    "Division of Nuclear Medicine, Department of Radiology, University of Miami Miller School of Medicine, Miami, FL"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Michele D. Stanchina"
    },
    {
      "affs": [
        1
      ],
      "name": "Russ A. Kuker"
    },
    {
      "affs": [
        2
      ],
      "name": "Sunwoo Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Craig H. Moskowitz"
    },
    {
      "affs": [
        3
      ],
      "name": "Mark K. Polar"
    },
    {
      "affs": [
        1
      ],
      "name": "Fei Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Tracy E. Crane"
    },
    {
      "affs": [
        1
      ],
      "name": "Melissa L. Lopez"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Pablo Alderuccio"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ffpsxggk5cbtw.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bneo.2026.100303",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717734/?tool=EBI",
  "id": "ffpsxggk5cbtw",
  "issns": [
    "2950-3280"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717734",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Lymphoid Neoplasia"
    ],
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7211950808",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717734/pdf/?tool=EBI",
  "pmcid": "PMC13717734",
  "pmid": "42959917",
  "published": "2026-09-08",
  "publisher": "The American Society of Hematology",
  "ris": "https://research.draconitic.com/paper/ffpsxggk5cbtw.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:39Z",
      "native_id": "PMC:PMC13717734",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717734"
    },
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42959917",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959917"
    },
    {
      "first_seen": "2026-11-02T12:22:00Z",
      "native_id": "PMC13717734",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bneo.2026.100303"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Impact of body composition on toxicity and response in patients with advanced-stage Hodgkin lymphoma treated with BV-AVD",
  "title_text": "Impact of body composition on toxicity and response in patients with advanced-stage Hodgkin lymphoma treated with BV-AVD",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:00Z",
  "url": "https://research.draconitic.com/paper/ffpsxggk5cbtw",
  "venue": "Blood neoplasia",
  "versions": []
}