{
  "abstract": "Background: Accurate evaluation of neoadjuvant chemotherapy (NAC) efficacy is critical for optimizing breast cancer treatment. This study investigates shear wave elastography (SWE) for quantifying stiffness changes within lesions and peri-lesional tissues (1–3 mm) and correlating these changes with pathological response to NAC.\n\nMethods: In a prospective cohort of 66 breast cancer patients, SWE parameters (Emax, Emean, Emin, Esd) were measured within tumors and surrounding tissues (1/2/3 mm) pre- and post-NAC. Pathological response was classified via Miller-Payne grading (G3-G5: effective; G1-G2: ineffective). Diagnostic performance was assessed using ROC curves.\n\nResults: Post-NAC, the effective group exhibited significant reductions in Emax, Emean, and Esd within lesions and peri-lesional regions (all P < 0.05), while the ineffective group maintained high stiffness. ΔEmax showed high apparent discrimination of pathological response: Intralesional ΔEmax: AUC = 0.941 (95% CI: 0.887-0.995), sensitivity 88.89%, specificity 85.71% (cutoff >49.12%). Peri-lesional ΔEmax (1–3 mm): AUC > 0.9, specificity >90%. The stiff rim sign disappeared exclusively in the effective group post-NAC.\n\nConclusion: SWE parameters (especially ΔEmax) and dynamic changes in the stiff rim sign are promising non-invasive biomarkers that correlate with pathological response to NAC. These findings support the potential role of SWE in post-treatment response evaluation, though prospective validation in larger cohorts is warranted before clinical implementation.",
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  "affiliations": [
    "Department of Ultrasound, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan",
    "Department of Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan",
    "Department of Otolaryngology, Kunming First People’s Hospital",
    "Yunnan Institute of Traditional Chinese Medicine, Yunnan University of Chinese Medicine",
    "Department of Pathology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan",
    "Department of Gastric and Small Intestinal Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan",
    "Department of Thyroid and Breast Surgery Department, The Second Affiliated Hospital of Kunming Medical University",
    "Department of Colorectal Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan"
  ],
  "article_type": null,
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  "authors": [
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        0
      ],
      "name": "Hongying Yang"
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    {
      "affs": [
        1
      ],
      "name": "Shan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaomao Luo"
    },
    {
      "affs": [
        1
      ],
      "name": "Zeng Zhang"
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    {
      "affs": [
        2
      ],
      "name": "Qin Su"
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    {
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        3
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      "name": "Wenjing Pu"
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    {
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        0
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      "name": "Haitao Chen"
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    {
      "affs": [
        1
      ],
      "name": "Qian An"
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    {
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        4
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      "name": "Xin Liu"
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    {
      "affs": [
        5
      ],
      "name": "Likun Luan"
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    {
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        6
      ],
      "name": "Ningxin Zhang"
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    {
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        7
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      "name": "Peijun Yao"
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    {
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      "name": "Yingxian Zhang"
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      "name": "Lei Zhang"
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    {
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      "name": "Jie Yu"
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    {
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        0
      ],
      "name": "Zhiyao Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhirui Chuan"
    }
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  "bibtex": "https://research.draconitic.com/paper/ffrf4s7gs5psj.bib",
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  "doi": "10.3389/fonc.2026.1839381",
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  "language": "en",
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  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
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  "title": "Assessment of shear wave elastography for evaluating neoadjuvant chemotherapy efficacy in breast cancer: correlation of stiffness changes with pathological response",
  "title_text": "Assessment of shear wave elastography for evaluating neoadjuvant chemotherapy efficacy in breast cancer: correlation of stiffness changes with pathological response",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:19Z",
  "url": "https://research.draconitic.com/paper/ffrf4s7gs5psj",
  "venue": "Frontiers in Oncology",
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