{
  "abstract": "We present a time-series single-nucleus ATAC-seq dataset from full-thickness excisional wounds in Sprague-Dawley rats. Samples were taken from unwounded skin (normal control) and at 1, 2, 5, 10, and 19 days post-wounding, spanning the inflammatory, proliferative, and remodeling phases of skin repair. We extracted nuclei with a two-step tissue dissociation protocol and prepared libraries using the DNBelab C Series Single-Nucleus ATAC Kit, then sequenced on the MGI DNBSEQ-T1 platform. After stringent quality filtering, 37,555 nuclei passed quality control; the resulting chromatin accessibility profiles cover 23 cell types: fibroblast subpopulations, keratinocytes, vascular endothelial cells, immune cells, and skin appendage cell types. This genome-wide chromatin accessibility dataset is a resource for studying regulatory dynamics during excisional wound repair and for comparing results with other wound healing systems.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "C. Chai"
    },
    {
      "name": "X. Ding"
    },
    {
      "name": "Y. Li"
    },
    {
      "name": "L. Liang"
    },
    {
      "name": "R. Huang"
    },
    {
      "name": "W. Zhang"
    },
    {
      "name": "R. Li"
    },
    {
      "name": "S. Xie"
    },
    {
      "name": "X. Zeng"
    },
    {
      "name": "L. Zhang"
    },
    {
      "name": "Y. Yuan"
    },
    {
      "name": "X. Wei"
    },
    {
      "name": "J. Wang"
    },
    {
      "name": "S. Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Ji"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ffsg9zwe1tq90.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.15.759293",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759293v1.full",
  "id": "ffsg9zwe1tq90",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759293v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7223082692",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759293v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ffsg9zwe1tq90.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:49Z",
      "native_id": "10.64898/2026.10.15.759293",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759293v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "Single-nucleus chromatin accessibility time course of excisional wound repair in rat skin",
  "title_text": "Single-nucleus chromatin accessibility time course of excisional wound repair in rat skin",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:49Z",
  "url": "https://research.draconitic.com/paper/ffsg9zwe1tq90",
  "venue": "bioRxiv",
  "versions": []
}