{
  "abstract": "We present a diagnostically challenging case of a 57-year-old male with new-onset persecutory delusions, hallucinations, functional decline, and gait instability following recent travel. While psychiatric features are recognised in Creutzfeldt-Jakob disease (CJD), they are often underappreciated as initial manifestations, leading to misdiagnosis and delayed recognition. Initially suspected to have a primary psychotic disorder, the patient's rapidly progressive course, neurological signs, characteristic MRI findings, and positive cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) confirmed a diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD). This case underscores the need to consider organic and neurodegenerative etiologies in patients with acute psychiatric symptoms and gait disturbance.",
  "abstract_shown": true,
  "affiliations": [
    "Gastroenterology and Hepatology, Newham University Hospital, Barts Health NHS Trust, London, GBR.",
    "Acute Medicine, Newham University Hospital, Barts Health NHS Trust, London, GBR.",
    "Geriatrics, Newham University Hospital, Barts Health NHS Trust, London, GBR."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gayathri Jayakumar"
    },
    {
      "affs": [
        1
      ],
      "name": "Eraj Rahman"
    },
    {
      "affs": [
        2
      ],
      "name": "Radhiya Ms Bakth"
    },
    {
      "affs": [
        1
      ],
      "name": "Abdurahman Moalin"
    },
    {
      "affs": [
        1
      ],
      "name": "Mosab Yousif"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fg1wyz95q197x.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116539",
  "fulltext_url": "https://europepmc.org/articles/PMC13679666",
  "id": "fg1wyz95q197x",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898936",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Prion Diseases and Protein Misfolding"
    ]
  ],
  "openalex": "W7213635169",
  "pdf_url": "https://europepmc.org/articles/PMC13679666?pdf=render",
  "pmcid": "PMC13679666",
  "pmid": "42898936",
  "published": "2026-09-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fg1wyz95q197x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42898936",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898936"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Prion Diseases and Protein Misfolding",
      "subfield": "molecular-biology"
    }
  ],
  "title": "When Psychosis Masks Neurodegeneration: A Case of Sporadic Creutzfeldt-Jakob Disease.",
  "title_text": "When Psychosis Masks Neurodegeneration: A Case of Sporadic Creutzfeldt-Jakob Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/fg1wyz95q197x",
  "venue": "Cureus",
  "versions": []
}