{
  "abstract": "Chitosan is a biocompatible and bioresorbable polymer family whose primary amine groups allow easy chemical modification through re-acetylation or functionalization, producing derivatives with tailored properties. While many chitosan derivatives have been characterized, detailed studies of ampholytic chitosan derivatives remain limited. This study investigates how the macromolecular structure of modified chitosans influences their physicochemical properties. The work focuses on chitosan functionalized with chelating ligands: polycarboxylates (DOTAGA, DTPA, EDTA) and the octadentate ligand DFO. Using several analytical techniques, the study examines the relationship between these structural modifications and resulting physicochemical behavior. A key contribution is a charge-based classification derived from two parameters: the mean charge of the repeat unit (c̅) and the charge fluctuation between adjacent units (δc 2 ). Based on charge fluctuation, chitosan derivatives are categorized into three groups: cationic derivatives (δc 2 < 0.5), weak polyampholytes (0.5 < δc 2 < 1.5), and strong polyampholytes (δc 2 > 1.5). This classification correlates strongly with measured properties such as isoelectric point, Newtonian viscosity, and polymer conformation in solution, including gyration and hydrodynamic radii at high ionic strength and polyelectrolyte peak behavior at low ionic strength. The results demonstrate that charge distribution is a key determinant of the solution behavior and physicochemical properties of chitosan derivatives.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Jordyn Ann Howard"
    },
    {
      "name": "Juan Felipe Salazar Ariza"
    },
    {
      "name": "Agnès Crépet"
    },
    {
      "name": "Alexander Zaderko"
    },
    {
      "name": "Catherine Ladavière"
    },
    {
      "name": "Fernande da Cruz-Boisson"
    },
    {
      "name": "François Lux"
    },
    {
      "name": "Olivier Tillement"
    },
    {
      "name": "Laurent David"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fg9w8wdzywyfx.bib",
  "cited_by": 0,
  "doi": "10.1016/j.carbpol.2026.125229",
  "fulltext_url": null,
  "id": "fg9w8wdzywyfx",
  "issns": [
    "0144-8617",
    "1879-1344"
  ],
  "landing_url": "https://hal.science/hal-05852611v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1606|Electrostatics and Colloid Interactions"
    ]
  ],
  "openalex": "W7140180826",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/fg9w8wdzywyfx.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:20:13Z",
      "native_id": "hal-05852611",
      "source": "hal",
      "url": "https://hal.science/hal-05852611v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1606|Electrostatics and Colloid Interactions",
      "subfield": "physical"
    }
  ],
  "title": "Impact of polyampholyte macromolecular structure on the conformation of chitosan derivatives",
  "title_text": "Impact of polyampholyte macromolecular structure on the conformation of chitosan derivatives",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:44Z",
  "url": "https://research.draconitic.com/paper/fg9w8wdzywyfx",
  "venue": "Carbohydrate Polymers",
  "versions": []
}