{
  "abstract": "Herein, we report a modular and redox-neutral strategy for the de novo synthesis of structurally diverse indolines. While conventional approaches often rely on prefunctionalized arenes or require oxidative/reductive steps, our method enables direct annulation from ortho-unsubstituted anilines and vinyldiazos. The sequence comprises a rhodium-catalyzed α-selective N–H insertion of vinyldiazoacetates, followed by TFA-promoted aza-Claisen rearrangement and intramolecular aza-Michael addition. This one-pot sequential protocol exhibits broad substrate generality and has been extended to an asymmetric version and intramolecular variant, allowing the synthesis of challenging seven-membered ring-fused indolines. DFT studies support a concerted mechanism via a chairlike transition state. With its operational simplicity and structural versatility, this methodology provides an efficient route to access privileged indoline scaffolds for pharmaceutical and synthetic applications.",
  "abstract_shown": true,
  "affiliations": [
    "Southern University of Science and Technology , , ,",
    "Henan Normal University , , , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Haifeng Long"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Meiling Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Weici Xu",
      "orcid": "0000-0003-3711-3220"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ming-Hua Xu",
      "orcid": "0000-0002-1692-2718"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fgvh6d538sxwc.bib",
  "cited_by": 0,
  "doi": "10.1021/acscentsci.6c00925",
  "fulltext_url": null,
  "id": "fgvh6d538sxwc",
  "issns": [
    "2374-7943",
    "2374-7951"
  ],
  "landing_url": "https://pubs.acs.org/acscii/article/doi/10.1021/acscentsci.6c00925/5446816/Fischer-Indole-Synthesis-Inspired-De-Novo-and",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Cyclopropane Reaction Mechanisms"
    ]
  ],
  "openalex": "W7220987535",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acscentsci.6c00925",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/fgvh6d538sxwc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:37Z",
      "native_id": "10.1021/acscentsci.6c00925",
      "source": "crossref",
      "url": "https://pubs.acs.org/acscii/article/doi/10.1021/acscentsci.6c00925/5446816/Fischer-Indole-Synthesis-Inspired-De-Novo-and"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Cyclopropane Reaction Mechanisms",
      "subfield": "organic"
    }
  ],
  "title": "Fischer Indole Synthesis Inspired De Novo and Modular Assembly of Indolines",
  "title_text": "Fischer Indole Synthesis Inspired De Novo and Modular Assembly of Indolines",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:37Z",
  "url": "https://research.draconitic.com/paper/fgvh6d538sxwc",
  "venue": "ACS Central Science",
  "versions": []
}