{
  "abstract": "Introduction\n\nSarcomas are rare, heterogeneous malignancies of mesenchymal origin whose diagnosis and molecular classification remain challenging. We introduced a oneclass anomaly detection framework to microRNA expression profiles to test whether sarcoma-associated miRNA features are distinguishable from those of epithelial, haematological, and neurological cancers and if these features carry any biological relevance.Methods\n\nCandidate miRNAs meeting cross-lineage significance criteria were further evaluated through differential expression analysis against subtype-matched normal mesenchymal reference tissue, pathway enrichment, and survival analysis. A five-miRNA index (\"Index 5\"), derived by Fisher's linear discriminant analysis with leave-one-out cross-validation in a TCGA-SARC training cohort, was applied without refitting to an independent external cohort (GSE36982).Results\n\nThe five-miRNA index (\"Index 5\") achieved an AUC of 0.93 and, applied without refitting to an independent external cohort (GSE36982), an AUC of 0.97. After Benjamini-Hochberg correction, one candidate miRNA (miR-1305) remained significantly associated with overall survival.Discussion\n\nThese findings identify a computationally derived, externally tested candidate miRNA signature associated with sarcoma. While this study lacks experimental and clinical validation, the broader aim of this study was to come up with a framework that would assist and speedup the exploratory candidate biomarker discovery process in rare malignancies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.",
    "Medical Faculty, Medical University of Warsaw, Warsaw, Poland.",
    "Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.",
    "Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland.",
    "Institute of Biochemistry and Biophysics Polish Academy of Science, Warsaw, Poland.",
    "Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.",
    "Outpatient Chemotherapy Department, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mritunjoy Dey"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Piotr Remiszewski",
      "orcid": "0009-0002-5170-6348"
    },
    {
      "affs": [
        2
      ],
      "name": "Ewelina Perdas"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Paweł Golik"
    },
    {
      "affs": [
        3
      ],
      "name": "Jakub Piątkowski"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Anna M Czarnecka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fgxsjatytrmwf.bib",
  "cited_by": 0,
  "doi": "10.3389/fgene.2026.1907450",
  "fulltext_url": "https://europepmc.org/articles/PMC13696034",
  "id": "fgxsjatytrmwf",
  "issns": [
    "1664-8021"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928931",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7221467907",
  "pdf_url": "https://europepmc.org/articles/PMC13696034?pdf=render",
  "pmcid": "PMC13696034",
  "pmid": "42928931",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fgxsjatytrmwf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928931",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928931"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|MicroRNA in disease regulation",
      "subfield": "oncology"
    }
  ],
  "title": "Cross-lineage anomaly detection of microRNA expression: a framework for deriving exploratory candidate biomarkers in sarcoma.",
  "title_text": "Cross-lineage anomaly detection of microRNA expression: a framework for deriving exploratory candidate biomarkers in sarcoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/fgxsjatytrmwf",
  "venue": "Frontiers in genetics",
  "versions": []
}