{
  "abstract": "BackgroundDigital mobility outcomes (DMOs) have been cited as potential clinical endpoints for trials in Parkinson's disease (PD). Current evidence from the Mobilise-D consortium suggests that selected DMOs are technically valid, with emerging research on their clinical validity. However, regulatory qualification of DMOs requires additional evidence of their meaningfulness to people with PD.ObjectiveTo identify meaningful DMOs by understanding how mobility symptoms impact aspects of health that matter to people with PD.MethodsPurposive sampling recruited a diverse sample of people with PD to participate in semi-structured interviews. Content analysis identified frequent and bothersome mobility symptoms and their impacts on meaningful aspects of health. Twelve experts mapped meaningful symptoms to relevant DMOs through a nominal group consensus.ResultsSeventy-two people with PD participated, inclusive of under-served groups: ethnic minorities (14%) or LGBTQIA + backgrounds (14%), in older age (3%) or with young-onset PD (13%), living rurally (31%) or in a deprived area (19%). Shuffling gait, bradykinesia and balance issues were the most frequent symptoms, and the most bothersome and impactful on meaningful aspects of health (i.e., activities of daily living, life-space mobility, emotional wellbeing) among participants who experienced them. Less frequent, but still highly bothersome and impactful symptoms included freezing of gait, fatigue and weakness. Expert consensus suggested that walking speed, stride length and turn duration were the most relevant DMOs to reflect these meaningful symptoms.ConclusionFindings offer an inclusive, meaningful framework for digital assessment of mobility in PD, grounded in lived experience and consistent with regulatory guidance.",
  "abstract_shown": true,
  "affiliations": [
    "Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.",
    "NIHR Newcastle Biomedical Research Centre, Newcastle University, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.",
    "Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.",
    "Insight for Data Analytics, University College Dublin, Dublin, Ireland.",
    "School of Medicine, Trinity College Dublin, Dublin, Ireland.",
    "Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, England.",
    "Mobilise-D Patient and Public Advisory Group, Newcastle upon Tyne, UK.",
    "Wolfson Institute of Population Health, Centre for Preventive Neurology, Queen Mary University of London, London, UK.",
    "Department of Neurology, The Royal London Hospital, Barts Health NHS Trust, London, UK.",
    "Department of Neurology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.",
    "Department of Rehabilitation Sciences, Research Group for Neurorehabilitation (eNRGy), KU Leuven, Leuven, Belgium.",
    "Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.",
    "Fraunhofer Institute for Integrated Circuits IIS, Erlangen, Germany.",
    "Laboratory for Early Markers of Neurodegeneration, Center for the study of Movement, Cognition and Mobility, Sagol School of Neuroscience, Faculty of Medicine and Health Sciences, Neurological Institute, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.",
    "Newcastle upon Tyne Hospitals NHS Foundations Trust, Newcastle upon Tyne, UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
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        0,
        1
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      "name": "Jack Lumsdon",
      "orcid": "0009-0001-8985-0209"
    },
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        1,
        2
      ],
      "name": "Ríona Mc Ardle",
      "orcid": "0000-0001-7959-3563"
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        0,
        1
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      "name": "Megan Hanrahan",
      "orcid": "0009-0006-1800-7042"
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    {
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        3,
        4
      ],
      "name": "Alison Keogh",
      "orcid": "0000-0001-5917-6308"
    },
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        0,
        5
      ],
      "name": "Cameron Wilson",
      "orcid": "0000-0001-5286-6306"
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        6
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      "name": "Tova Gur Arieh"
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        7,
        8
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      "name": "Alastair J Noyce",
      "orcid": "0000-0003-3027-5497"
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      "name": "Essa Bhadra"
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      "name": "Johanna Graeber"
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    {
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        10
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      "name": "Lova Hulst"
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    {
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        10
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      "name": "Moran Gilat",
      "orcid": "0000-0002-0072-4637"
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        11,
        12
      ],
      "name": "Heiko Gassner",
      "orcid": "0000-0003-2037-9460"
    },
    {
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        11
      ],
      "name": "Jürgen Winkler",
      "orcid": "0000-0003-0630-9204"
    },
    {
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        9
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      "name": "Walter Maetzler",
      "orcid": "0000-0002-5945-4694"
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        13
      ],
      "name": "Anat Mirelman"
    },
    {
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        1,
        2,
        14
      ],
      "name": "Alison J Yarnall",
      "orcid": "0000-0002-3126-9163"
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    {
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        1,
        2
      ],
      "name": "Lynn Rochester",
      "orcid": "0000-0001-5774-9272"
    },
    {
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        0
      ],
      "name": "Katie Brittain",
      "orcid": "0000-0002-3889-7357"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fh8xjbvc1qnbz.bib",
  "cited_by": 0,
  "doi": "10.1177/1877718x261494917",
  "fulltext_url": "https://europepmc.org/articles/PMC13652976",
  "id": "fh8xjbvc1qnbz",
  "issns": [
    "1877-7171",
    "1877-718X"
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  "landing_url": "https://europepmc.org/article/MED/42852984",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3612|Balance, Gait, and Falls Prevention"
    ]
  ],
  "openalex": "W7221191536",
  "pdf_url": "https://europepmc.org/articles/PMC13652976?pdf=render",
  "pmcid": "PMC13652976",
  "pmid": "42852984",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fh8xjbvc1qnbz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42852984",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42852984"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2728|Parkinson's Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Meaningful digital mobility outcomes for people with Parkinson's disease: Insights grounded in diverse lived experience.",
  "title_text": "Meaningful digital mobility outcomes for people with Parkinson's disease: Insights grounded in diverse lived experience.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/fh8xjbvc1qnbz",
  "venue": "Journal of Parkinson's disease",
  "versions": []
}