{
  "abstract": "The amygdala and hippocampus are key structures in emotional processing, yet the transient neural dynamics coordinating their interaction remain poorly understood. We simultaneously recorded single-neuron activity and local field potentials from these regions in epilepsy patients performing an emotional image-rating task. Neurons in both regions exhibited firing rate changes predictive of subjective emotional valence. While conventional spectral analysis revealed no valence-specific patterns, beta bursts (13-30 Hz)-transient, high-power events-were selectively modified by task features. In both regions, beta bursts were associated with increased gamma amplitude and enhanced phase coherence, with beta-gamma phase-amplitude coupling capturing emotion-related dynamics. Critically, amygdala beta bursts were associated with valence-dependent, bidirectional modulation of hippocampal interneuron firing - decreased during very unpleasant/highest arousal processing and increased during high-arousal very pleasant processing - while putative pyramidal-cell firing did not change significantly. Hippocampal bursts showed no reciprocal influence. These findings suggest that beta bursts may represent a temporally precise neural correlate of emotional appraisal and a potential target for neuromodulation in mood disorders.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Yajun Zhou",
      "orcid": "0000-0003-3044-4959"
    },
    {
      "name": "Yuqing Huang",
      "orcid": "0000-0001-7955-824X"
    },
    {
      "name": "Giana F. Pittaro"
    },
    {
      "name": "Behzad Zareian"
    },
    {
      "name": "Ayman Aljishi"
    },
    {
      "name": "Alondra P. Toro"
    },
    {
      "name": "Zion Zibly"
    },
    {
      "name": "Sami Obaid"
    },
    {
      "name": "Adithya Sivaraju",
      "orcid": "0000-0002-6027-9205"
    },
    {
      "name": "Ilan Harpaz-Rotem",
      "orcid": "0000-0002-6066-9406"
    },
    {
      "name": "Alfred Kaye",
      "orcid": "0000-0002-3153-1221"
    },
    {
      "name": "John Krystal",
      "orcid": "0000-0001-6952-1726"
    },
    {
      "name": "Kevin Sheth",
      "orcid": "0000-0003-2003-5473"
    },
    {
      "name": "Xiaosi Gu",
      "orcid": "0000-0002-9373-987X"
    },
    {
      "name": "Christopher Pittenger",
      "orcid": "0000-0003-2117-9321"
    },
    {
      "name": "Eyiyemisi C. Damisah",
      "orcid": "0000-0001-8854-1335"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fhcgyjyn68scz.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77952-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13720044",
  "id": "fhcgyjyn68scz",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77952-9",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "2805|Neural dynamics and brain function"
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  ],
  "openalex": "W7215123842",
  "pdf_url": "https://www.nature.com/articles/s41467-026-77952-9.pdf",
  "pmcid": "PMC13720044",
  "pmid": "42957703",
  "published": "2026-10-01",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/fhcgyjyn68scz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-77952-9",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77952-9"
    },
    {
      "first_seen": "2026-11-01T00:20:44Z",
      "native_id": "MED:42957703",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957703"
    },
    {
      "first_seen": "2026-11-02T12:23:54Z",
      "native_id": "PMC13720044",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77952-9"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Neural dynamics and brain function",
      "subfield": "neuroscience"
    }
  ],
  "title": "Amygdala beta bursts modulate hippocampal neuronal dynamics during human emotional processing",
  "title_text": "Amygdala beta bursts modulate hippocampal neuronal dynamics during human emotional processing",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:00Z",
  "url": "https://research.draconitic.com/paper/fhcgyjyn68scz",
  "venue": "Nature Communications",
  "versions": []
}