{
  "abstract": "To enhance the understanding of lineage switch (LS), we retrospectively analyzed the clinical data of a patient with KMT2A-rearranged acute lymphoblastic leukemia (ALL) who underwent a LS at relapse and reviewed the relevant literature. The patient, a 23-year-old woman, was initially diagnosed with ALL (KMT2A::AFF1-positive). She experienced a relapse during consolidation chemotherapy and achieved a second remission following chemotherapy containing blinatumomab, subsequently bridging to allogeneic stem cell transplantation. Approximately 2 months after transplantation, extensive extramedullary relapse occurred. Immunohistochemical analysis of the extramedullary mass revealed a partial loss of CD19 expression and emergence of MPO expression, whereas the KMT2A rearrangement was retained. After receiving CD19-CAR-T therapy, the patient experienced another extramedullary relapse, at which time complete loss of CD19 expression and positivity for MPO were observed, leading to a diagnosis of myeloid sarcoma. Ultimately, the family opted to discontinue treatment and the patient was discharged to receive care locally. Following antigen-targeted immunotherapy, LS, as a potential mechanism of drug resistance and adaptation, warrants increased clinical attention.",
  "abstract_shown": true,
  "affiliations": [
    "Senior Department of Hematology, Chinese PLA General Hospital, Beijing 100071, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Z Q Qiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Y P Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "L D Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fhkwqp9kksy43.bib",
  "cited_by": 0,
  "doi": "10.3760/cma.j.cn121090-20260228-00114",
  "fulltext_url": "https://europepmc.org/articles/PMC13669441",
  "id": "fhkwqp9kksy43",
  "issns": [
    "0253-2727",
    "2707-9740"
  ],
  "landing_url": "https://europepmc.org/article/MED/42851184",
  "language": "chi",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Acute Lymphoblastic Leukemia research"
    ]
  ],
  "openalex": "W7221091402",
  "pdf_url": "https://europepmc.org/articles/PMC13669441?pdf=render",
  "pmcid": "PMC13669441",
  "pmid": "42851184",
  "published": "2026-08-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fhkwqp9kksy43.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42851184",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42851184"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Acute Lymphoblastic Leukemia research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "[KMT2A-rearranged acute lymphoblastic leukemia with lineage switch following relapse: a case report and literature review].",
  "title_text": "[KMT2A-rearranged acute lymphoblastic leukemia with lineage switch following relapse: a case report and literature review].",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/fhkwqp9kksy43",
  "venue": "Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi",
  "versions": []
}