{
  "abstract": "Methylparaben (MEP), a widespread preservative, raises neurotoxicity concerns through oxidative stress and inflammation. Resveratrol (RES) is a natural polyphenol with antioxidant and anti-inflammatory properties. This study investigated whether RES protects against MEP-induced neurotoxicity in female rats. Female Wistar rats were divided into five groups (n=10/group): control, vehicle (5% DMSO), MEP alone (200 mg/kg, s.c., 15 days), RES alone (20 mg/kg, i.p., 15 days), and MEP+RES co-treatment. We evaluated anxiety-like behavior (elevated plus maze), brain histopathology (cortex/hippocampus), oxidative stress markers (GSH, SOD), stress-related gene expression (Nrf2, ASK1, PP-1cs, PP-2Acs by qPCR), inflammatory proteins (TNF-α, IL-6 by immunohistochemistry), and apoptotic markers (BAX, BCL-2). MEP exposure significantly increased anxiety-like behavior, caused structural damage in cortex and hippocampus, depleted GSH and SOD, upregulated Nrf2, ASK1, PP-1cs, and PP-2Acs, elevated TNF-α, IL-6, and pro-apoptotic BAX, while reducing BCL-2. RES alone caused no adverse effects. Remarkably, RES co-administration significantly attenuated and partially restored MEP-induced alterations, restoring behavior, tissue architecture, antioxidant defenses, gene expression, and immune balance. RES effectively attenuates MEP-induced neurotoxicity through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, positioning it as a promising neuroprotective agent against environmental toxicants.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.",
    "Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.",
    "Faculty of Medicine and Health Sciences, Medical School, University of Nottingham, Nottingham NG7 2QL, UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Entesar AlShammari"
    },
    {
      "affs": [
        0
      ],
      "name": "Promy Virk"
    },
    {
      "affs": [
        1
      ],
      "name": "Dalal Alkhelb"
    },
    {
      "affs": [
        1
      ],
      "name": "Fawaz Alasmari"
    },
    {
      "affs": [
        0
      ],
      "name": "Wasayf Alotibi"
    },
    {
      "affs": [
        2
      ],
      "name": "Nouf Alsultan"
    },
    {
      "affs": [
        0
      ],
      "name": "Gadah Albasher"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fhtstkrbb6cqw.bib",
  "cited_by": 0,
  "doi": "10.7150/ijms.138134",
  "fulltext_url": "https://europepmc.org/articles/PMC13685036",
  "id": "fhtstkrbb6cqw",
  "issns": [
    "1449-1907"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909400",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2717|Sirtuins and Resveratrol in Medicine"
    ]
  ],
  "openalex": "W7214675184",
  "pdf_url": "https://europepmc.org/articles/PMC13685036?pdf=render",
  "pmcid": "PMC13685036",
  "pmid": "42909400",
  "published": "2026-09-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fhtstkrbb6cqw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42909400",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909400"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2717|Sirtuins and Resveratrol in Medicine",
      "subfield": "general"
    }
  ],
  "title": "Effects of Resveratrol on Anxiety-Like Behavior, Neuronal Damage, and Apoptotic Signaling in Female Rats Exposed to Methylparaben.",
  "title_text": "Effects of Resveratrol on Anxiety-Like Behavior, Neuronal Damage, and Apoptotic Signaling in Female Rats Exposed to Methylparaben.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/fhtstkrbb6cqw",
  "venue": "International journal of medical sciences",
  "versions": []
}