{
  "abstract": "Although diphtheria toxin-like ADP-ribosyltransferases (ARTDs) are implicated in host-virus interactions, the specific antiviral mechanisms of certain family members remain largely undefined. Here, we reveal that mono-ADP-ribosyltransferase PARP10 restricts viral replication by forming biomolecular condensates via multivalent interactions among its structured domains. PARP10 condensates enhance enzymatic activity, resulting in increased NAD⁺ consumption that ultimately inhibits viral replication. The antiviral effects of PARP10 are shown to require both its catalytic activity and NAD⁺ regulation, as catalytic mutants and PARP10 inhibitors abrogate these effects, while reduction of NAD⁺ potently restricts viral replication. Furthermore, we identify auto-ADP-ribosylation as an intrinsic negative feedback mechanism modulating PARP10 condensation. These findings establish PARP10 condensation as a compartmentalization strategy that amplifies local NAD⁺ consumption to safeguard host antiviral immunity.",
  "abstract_shown": true,
  "affiliations": [
    "Fudan University, Shanghai, China",
    "State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China",
    "Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China",
    "School of Future Biomedicine, Westlake University, Hangzhou, China",
    "Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xiaoxin Chen",
      "orcid": "0009-0007-3237-1606"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Qi Xu",
      "orcid": "0000-0002-9480-4776"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Yi Liu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Zhenshuo Zhu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ziqiu Wang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Yun Zhang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ziru Li"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Yunan Mao"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Chenmiao Ai"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Qi Chen"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Le Tian"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Zhiying Yao"
    },
    {
      "affs": [
        4
      ],
      "name": "Youngdae Gwon",
      "orcid": "0000-0002-5618-9370"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Zhubing Shi",
      "orcid": "0000-0002-9624-4960"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Peiguo Yang",
      "orcid": "0000-0002-2334-5664"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fj14q2zwk8h6y.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78058-y",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710856/",
  "id": "fj14q2zwk8h6y",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-78058-y",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|interferon and immune responses"
    ]
  ],
  "openalex": "W7214464417",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78058-y_reference.pdf",
  "pmcid": "PMC13710856",
  "pmid": "42934229",
  "published": "2026-09-26",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/fj14q2zwk8h6y.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:44Z",
      "native_id": "PMC13710856",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-78058-y"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|interferon and immune responses",
      "subfield": "immunology"
    }
  ],
  "title": "PARP10 condensation inhibits viral replication via targeting NAD+ homeostasis",
  "title_text": "PARP10 condensation inhibits viral replication via targeting NAD+ homeostasis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:44Z",
  "url": "https://research.draconitic.com/paper/fj14q2zwk8h6y",
  "venue": "Nature Communications",
  "versions": []
}