{
  "abstract": "Introduction\n\nThe clinical efficacy of platinum-based chemotherapy in ovarian cancer is limited by insufficient drug retention within the peritoneal cavity and associated systemic toxicity. This study aimed to develop hydrophobically modified chitosan nanomicelles as a carrier system for localized carboplatin delivery.Methods\n\nHydrophobically modified chitosan nanomicelles were prepared using an oil-in-watr emulsification technique and characterized in terms of their physicochemical properties, stability, encapsulation efficiency, and drug release behaviour. In vitro studies were performed to assess biocompatibility and cellular internalization in MUC1-expressing SK-OV-3 ovarian cancer cells. The preliminary in vivo antitumour response to the carboplatin-loaded nanomicelles was further evaluated in a subcutaneous murine ovarian cancer xenograft model.Results\n\nThe obtained nanomicelles exhibited a mean hydrodynamic diameter of approximately 200 nm and an encapsulation efficiency of 44%. No quantifiable carboplatin release was detected within 24 h under the tested conditions; however, the absence of a quantifiable signal cannot distinguish limited early release from release below the quantifiable range of the analytical method. The nanomicelles demonstrated preliminary in vitro cytocompatibility in SK-OV-3 cells, with mean cell viability remaining above 70% under the tested conditions, and intracellular localization of the nanomicelles in MUC1-expressing SK-OV-3 cells was observed by confocal microscopy. At the end-point evaluation, tumours were significantly smaller in the nanomicelle-treated group than in the free-carboplatin group (p = 0.03), whereas exploratory longitudinal analysis of tumour-growth AUC showed no significant between-group difference (p = 0.67).Conclusion\n\nHydrophobically modified chitosan nanomicelles represent a feasible carrier platform for localized carboplatin delivery and warrant further investigation for potential intraperitoneal application. The observed drug encapsulation, lack of quantifiable carboplatin release during the 24-h study period, preliminary in vitro cytocompatibility in SK-OV-3 cells, cellular internalization, and preliminary antitumour response provide proof-of-concept support for continued evaluation of this carrier system.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Polymer and Biomaterials Science, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Szczecin, Poland.",
    "Department of Physiology, Pomeranian Medical University in Szczecin, Szczecin, Poland.",
    "Department of Biology, Parasitology and Pharmaceutical Botany, Pomeranian Medical University in Szczecin, Szczecin, Poland.",
    "Department of Pharmacology, Pomeranian Medical University in Szczecin, Szczecin, Poland.",
    "Laboratory of Pharmacodynamics, Pomeranian Medical University in Szczecin, Szczecin, Poland.",
    "Department of Functional Anatomy, Pomeranian Medical University in Szczecin, Szczecin, Poland.",
    "Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, Szczecin, Poland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Agnieszka Piegat",
      "orcid": "0000-0001-9586-4570"
    },
    {
      "affs": [
        1
      ],
      "name": "Katarzyna Piotrowska"
    },
    {
      "affs": [
        2
      ],
      "name": "Danuta Kosik-Bogacka"
    },
    {
      "affs": [
        3
      ],
      "name": "Joanna Łapczuk-Romanska"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Radosław Birger",
      "orcid": "0009-0008-6256-5695"
    },
    {
      "affs": [
        3
      ],
      "name": "Nina Komaniecka"
    },
    {
      "affs": [
        3
      ],
      "name": "Marek Drozdzik"
    },
    {
      "affs": [
        5
      ],
      "name": "Agnieszka Kempinska-Podhorodecka"
    },
    {
      "affs": [
        6
      ],
      "name": "Aneta Cymbaluk-Ploska"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fj2vacszqc7fw.bib",
  "cited_by": 0,
  "doi": "10.2147/ijn.s634858",
  "fulltext_url": "https://europepmc.org/articles/PMC13675965",
  "id": "fj2vacszqc7fw",
  "issns": [
    "1176-9114",
    "1178-2013"
  ],
  "landing_url": "https://europepmc.org/article/MED/42892969",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7221439459",
  "pdf_url": "https://europepmc.org/articles/PMC13675965?pdf=render",
  "pmcid": "PMC13675965",
  "pmid": "42892969",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fj2vacszqc7fw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42892969",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42892969"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Evaluation of Modified Chitosan Nanomicelles with Carboplatin for Effective Treatment Against Ovarian Cancer Cell Types in Murine Model.",
  "title_text": "Evaluation of Modified Chitosan Nanomicelles with Carboplatin for Effective Treatment Against Ovarian Cancer Cell Types in Murine Model.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/fj2vacszqc7fw",
  "venue": "International journal of nanomedicine",
  "versions": []
}