{
  "abstract": "This case report describes the management of a complex volumetric muscle loss (VML) injury in a 3-year-old mixed-breed dog following severe trauma to the right forelimb, which resulted in extensive multi-muscle defects that were unsuitable for primary closure. After initial stabilization and surgical debridement, reconstruction was achieved using a transpositional flap, while a gold nanoparticles-bioactive glass-alginate-cellulose (BGAuSP-Alg-MCC) composite was implanted to fill the dead space and support tissue regeneration. Postoperative healing was evaluated through clinical follow-up, computed tomography performed immediately and at 1 and 3 months postoperatively, as well as histological and immunohistochemical analyses. Imaging demonstrated progressive integration of the biomaterial, restoration of tissue density comparable to adjacent muscle, and absence of major complications. Histological evaluation demonstrated moderate inflammation and granulation tissue formation, containing numerous blood capillaries (neoangiogenesis), confirmed by CD31 and α-Smooth muscle actin (SMA) immunolabelling. Functional recovery was favorable, with preserved limb mobility and normal gait. These findings provide preliminary evidence of local biocompatibility and support the feasibility of incorporating the BGAuSP-Alg-MCC composite into a multimodal surgical management approach for extensive volumetric muscle loss in canine patients.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, Cluj-Napoca, 400372, Romania.",
    "Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, Cluj-Napoca, 400271, Romania.",
    "Doctoral School in Physics, Faculty of Physics, Babeș-Bolyai University, M. Kogălniceanu 1, Cluj-Napoca, 400084, Romania.",
    "Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, Cluj-Napoca, 400271, Romania. klara.magyari@ubbcluj.ro.",
    "INSPIRE Research Platform InfoBioNano4Health & Biomedical Imaging, Babeș-Bolyai University, Cluj-Napoca, 400084, Romania. klara.magyari@ubbcluj.ro."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alina Zăvoi"
    },
    {
      "affs": [
        0
      ],
      "name": "Tom Ablassmaier"
    },
    {
      "affs": [
        0
      ],
      "name": "Bianca Pop"
    },
    {
      "affs": [
        0
      ],
      "name": "Ștefana Mureșan"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrada Negoescu"
    },
    {
      "affs": [
        0
      ],
      "name": "Felix Lucaci"
    },
    {
      "affs": [
        0
      ],
      "name": "Robert Purdoiu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Alexandra Feraru"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Klara Magyari",
      "orcid": "0000-0003-1770-8454"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucia Bel"
    },
    {
      "affs": [
        0
      ],
      "name": "Mădălina Dragomir"
    },
    {
      "affs": [
        0
      ],
      "name": "Liviu Oana"
    },
    {
      "affs": [
        0
      ],
      "name": "Marian Taulescu"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandra Dreancă"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fjer3zwesf4jt.bib",
  "cited_by": 0,
  "doi": "10.1007/s11259-026-11557-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13652933",
  "id": "fjer3zwesf4jt",
  "issns": [
    "0165-7380",
    "1573-7446"
  ],
  "landing_url": "https://europepmc.org/article/MED/42853324",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7221152627",
  "pdf_url": "https://europepmc.org/articles/PMC13652933?pdf=render",
  "pmcid": "PMC13652933",
  "pmid": "42853324",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fjer3zwesf4jt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:12Z",
      "native_id": "MED:42853324",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42853324"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Management of volumetric muscle loss in a dog using bioactive glass-alginate-cellulose composite and a transpositional flap: a case report.",
  "title_text": "Management of volumetric muscle loss in a dog using bioactive glass-alginate-cellulose composite and a transpositional flap: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:12Z",
  "url": "https://research.draconitic.com/paper/fjer3zwesf4jt",
  "venue": "Veterinary research communications",
  "versions": []
}