{
  "abstract": "Radiotherapy is increasingly combined with CAR T cell therapy in B cell lymphomas, but treatment outcome may depend on the irradiation modality. We evaluated minibeam radiation therapy (MBRT) as a partner for CD19 CAR T cells in an orthotopic primary central nervous system (CNS) lymphoma model in immunodeficient rats. CAR T therapy prolonged survival compared with untreated controls. MBRT at 30 Gy followed by CAR T cells five days later produced the longest median survival among radiotherapy-containing regimens and improved outcome compared with conventional radiotherapy (CRT) based combinations. Histopathological findings were consistent with these survival differences. However, MBRT plus CAR T therapy did not significantly outperform CAR T monotherapy. These results indicate that MBRT provides a favorable, non-antagonistic radiotherapy context for CAR T therapy and suggest that radiation modality should be considered when designing combinations of radiotherapy with adoptive cellular therapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Lorea Iturri"
    },
    {
      "name": "Sarah Potiron"
    },
    {
      "name": "Liangchao Sun"
    },
    {
      "name": "Marjorie Juchaux"
    },
    {
      "name": "Cristèle Gilbert"
    },
    {
      "name": "Julie Espenon"
    },
    {
      "name": "Ignacio Anegon"
    },
    {
      "name": "Severine Ménoret"
    },
    {
      "name": "Carole Soussain"
    },
    {
      "name": "Sebastián Amigorena"
    },
    {
      "name": "Marion Alcantara"
    },
    {
      "name": "Yolanda Prezado",
      "orcid": "0000-0001-5957-2327"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fjsv1870y0t9d.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117827",
  "fulltext_url": "https://europepmc.org/articles/PMC13677572",
  "id": "fjsv1870y0t9d",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03208-6",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Health sciences"
    ],
    [
      "heading",
      "Internal medicine"
    ],
    [
      "heading",
      "Medical specialty"
    ],
    [
      "heading",
      "Medicine"
    ],
    [
      "heading",
      "Neurology"
    ],
    [
      "openalex",
      "2730|CAR-T cell therapy research"
    ]
  ],
  "openalex": "W7220926527",
  "pdf_url": "https://europepmc.org/articles/PMC13677572?pdf=render",
  "pmcid": "PMC13677572",
  "pmid": "42898331",
  "published": "2026-10-08",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/fjsv1870y0t9d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117827",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03208-6"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117827",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032086"
    },
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898331",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898331"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Minibeam radiation therapy supports CAR T therapy in a rat model of CNS lymphoma",
  "title_text": "Minibeam radiation therapy supports CAR T therapy in a rat model of CNS lymphoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/fjsv1870y0t9d",
  "venue": "iScience",
  "versions": []
}