{
  "abstract": "Background/Aim: Breast cancer (BC) remains a major health threat, highlighting the need for accessible screening. Characteristics of the cardiovascular system can be altered in BC patients. This study explored a noninvasive method combining arterial pulse-waveform analysis and classification to compare arterial pulse-waveform characteristics between BC patients (n = 51)) and age-matched controls (n = 76)).\n\nMethods: From one-minute radial waveform recordings, 40 harmonic indices (amplitude proportions, phase angles, and their variability) were derived. Significant differences in pulse-waveform indices were observed between groups, suggesting altered pulse-wave transmission conditions in BC patients. Two classifiers were compared: machine learning and a novel pulse-distribution analysis (PDA).\n\nResults: PDA demonstrated an acceptable discrimination with an AUC of 0.74, outperforming machine learning (AUC up to 0.58). Subgroup analysis by clinical factors such as TNM stage showed variable performance, with AUCs ranging from 0.66-0.93. Discrimination appeared to improve with disease progression (AUC 0.86 for stage IV), suggesting that tumor-induced vascular alterations may affect pulse-wave transmission.\n\nConclusion: The primary contribution of this work is the identification of distinct pulse-waveform signatures in BC patients, providing a physiological basis for future development of noninvasive screening tools. The proposed method, characterized by its low cost and ease of use, warrants further validation in larger cohorts.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s13239-026-00842-0.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Traditional Medicine, College of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan",
    "Department of Traditional Chinese Medicine, Taipei City Hospital RenAi Branch, Taipei, Taiwan",
    "Department of Recreation and Sport Management, University of Taipei, Taipei, Taiwan",
    "School of Chinese Medicine, College of Medicine, National Yang-Ming Chiao-Tung University, 155, Li-Nong St, Sec 2, Peitou, Taipei, Taiwan",
    "Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, No.43, Section 4, Keelung Road, Taipei, Taiwan",
    "Division of Hematology and Oncology, Department of Medicine, Taipei City Hospital, Renai Branch, Taipei, Taiwan",
    "Department of traditional Chinese medicine, National Yang-Ming Chiao-Tung University Hospital, Yilan, Taiwan",
    "Biomedical Engineering Research Center, National Defense Medical University, Taipei, Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Chao-Tsung Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Ting-Wei Yeh"
    },
    {
      "affs": [
        5
      ],
      "name": "Yi-Sheng Chou"
    },
    {
      "affs": [
        5
      ],
      "name": "Chi-Feng Cheng"
    },
    {
      "affs": [
        5
      ],
      "name": "Yi-Hsuan Lai"
    },
    {
      "affs": [
        0,
        3,
        6
      ],
      "name": "Chung-Hua Hsu"
    },
    {
      "affs": [
        4,
        7
      ],
      "name": "Hsin Hsiu",
      "orcid": "0000-0001-6761-3774"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fjzfsxznw45tk.bib",
  "cited_by": 0,
  "doi": "10.1007/s13239-026-00842-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723660/",
  "id": "fjzfsxznw45tk",
  "issns": [
    "1869-408X",
    "1869-4098"
  ],
  "landing_url": "https://doi.org/10.1007/s13239-026-00842-0",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2705|Cardiovascular Health and Disease Prevention"
    ]
  ],
  "openalex": "W7161580704",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s13239-026-00842-0.pdf",
  "pmcid": "PMC13723660",
  "pmid": "42151707",
  "published": "2026-05-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fjzfsxznw45tk.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:15Z",
      "native_id": "PMC13723660",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s13239-026-00842-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Health and Disease Prevention",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Discriminating Breast Cancer Patients by Spectral Analysis of Arterial Pulse Waveforms",
  "title_text": "Discriminating Breast Cancer Patients by Spectral Analysis of Arterial Pulse Waveforms",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:26Z",
  "url": "https://research.draconitic.com/paper/fjzfsxznw45tk",
  "venue": "Cardiovascular Engineering and Technology",
  "versions": []
}