{
  "abstract": "Mannose triflate is an established precursor for nucleophilic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) production, but same-scale, stage-resolved process behavior is incompletely documented. This retrospective study combines three 100 g D-mannose confirmation batches with exploratory process-deviation observations. Stage III (orthoester isolation), Stage IV (selective hydrolysis), and Stage V (triflation) showed recorded yield relative standard deviations (RSDs) of 9.7%, 14.5%, and 2.0%, respectively. Recovery of contemporaneous process-validation and research and development (R&D) records provided direct batch-specific Stage III outputs and Stage IV/V charges and outputs, resolving the principal yield-denominator ambiguity; one archived Stage IV-to-V carry-forward mismatch in MT-09.06.004 remains explicitly unresolved. Elevated Stage IV evaporation temperature (20/36 °C versus ≤12–13 °C) produced an additional component on thin-layer chromatography (TLC) and was followed by a 15-peak gas chromatography (GC) mixture; shortened Stage II bromination and hexane-only Stage III isolation were also associated with poorer downstream outcomes. A single Stage VI dichloromethane/cyclohexane trial recovered 31.36 g from 34.0 g (92.2% rounded). Three later batches showed 97.6–98.1% high-performance liquid chromatography (HPLC) assay and 0.07–0.12% total impurities. One nonclinical radiosynthesis showed that the synthesized precursor underwent nucleophilic [18F]fluorination (69.4% decay-corrected yield; 99.7% radio-HPLC area); no in vivo validation was performed. The principal contribution is a stage-resolved map of process sensitivity rather than a new synthetic route or a validated good manufacturing practice (GMP) process.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Faculty of Science, Yildiz Technical University, Davutpasa Campus, Istanbul 34220, Türkiye",
    "Moleküler Görüntüleme San. ve Tic. A.Ş., TÜBİTAK-MAM Technology Free Zone, Gebze 41470, Türkiye"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Gökhan Özokan",
      "orcid": "0000-0003-1140-1996"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fk1wv22qmp776.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31203616",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707591/?tool=EBI",
  "id": "fk1wv22qmp776",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/20/3616",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Radiopharmaceutical Chemistry and Applications"
    ]
  ],
  "openalex": "W7221544731",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707591/pdf/?tool=EBI",
  "pmcid": "PMC13707591",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/fk1wv22qmp776.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31203616",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/20/3616"
    },
    {
      "first_seen": "2026-10-30T12:21:46Z",
      "native_id": "PMC:PMC13707591",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13707591"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Radiopharmaceutical Chemistry and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "Multibatch Analysis of Process Sensitivity Across Stages in 100 g Scale Mannose Triflate Synthesis",
  "title_text": "Multibatch Analysis of Process Sensitivity Across Stages in 100 g Scale Mannose Triflate Synthesis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:46Z",
  "url": "https://research.draconitic.com/paper/fk1wv22qmp776",
  "venue": "Molecules",
  "versions": []
}