{
  "abstract": "Background: As the starting segment of the digestive tract, the oral cavity harbors a complex microbial community that closely interacts with the distal gut microbiota. Recent evidence suggests that oral hygiene status and oral dysbiosis may correlate with gut microbial homeostasis and play a potential role in the initiation or exacerbation of small intestinal bacterial overgrowth (SIBO).\n\nObjective: This review aims to integrate existing evidence, outline a hypothesis-generating framework, identify critical knowledge gaps, and provide new perspectives for future interdisciplinary mechanistic research and clinical translation in SIBO and related gastrointestinal disorders.\n\nDesign: This narrative review synthesizes and evaluates preliminary clinical correlations, metagenomic surveys, and animal models that support the oral microbiota as a potentially modifiable factor associated with SIBO, and discusses the proposed underlying molecular pathways.\n\nResults: Existing evidence supports the oral microbiota as a potentially modifiable factor associated with SIBO. However, direct high-level evidence testing oral hygiene interventions against definitive SIBO outcomes is currently lacking.\n\nConclusions: The oral-gut axis may play a critical role in SIBO pathogenesis. Future research requires high-quality clinical trials to validate the impact of oral hygiene interventions on SIBO outcomes, bridging the current critical knowledge gaps.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, the First Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, People's Republic of China",
    "Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province, People's Republic of China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lin He",
      "orcid": "0009-0003-9392-7998"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Wang",
      "orcid": "0009-0000-2675-0641"
    },
    {
      "affs": [
        1
      ],
      "name": "Tao Bai",
      "orcid": "0000-0001-9697-8510"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaohua Hou",
      "orcid": "0000-0002-4777-7920"
    },
    {
      "affs": [
        0
      ],
      "name": "Di Ran"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Yang",
      "orcid": "0009-0007-6905-9173"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fkg3vww0xb795.bib",
  "cited_by": 0,
  "doi": "10.1080/20002297.2026.2735085",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721802/?tool=EBI",
  "id": "fkg3vww0xb795",
  "issns": [
    "2000-2297"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13721802",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7224583165",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721802/pdf/?tool=EBI",
  "pmcid": "PMC13721802",
  "pmid": "42964722",
  "published": "2026-10-28",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/fkg3vww0xb795.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13721802",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13721802"
    },
    {
      "first_seen": "2026-11-03T12:22:26Z",
      "native_id": "PMC13721802",
      "source": "pmc",
      "url": "https://doi.org/10.1080/20002297.2026.2735085"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Does the mouth seed the small bowel? Mechanisms and hypothesis-generating framework via the oral–gut axis",
  "title_text": "Does the mouth seed the small bowel? Mechanisms and hypothesis-generating framework via the oral–gut axis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:26Z",
  "url": "https://research.draconitic.com/paper/fkg3vww0xb795",
  "venue": "Journal of oral microbiology",
  "versions": []
}