{
  "abstract": "Unique physicochemical properties of ferritin nanoparticles, such as high biocompatibility, precise structural assembly, and modular surface chemistry make them a promising biomimetic platform for the delivery of therapeutic and diagnostic agents, including radioactive isotopes. However, the translation of ferritin from laboratory-scale synthesis to clinical applications remains hindered by the lack of standardized analytical workflows and requires precise qualitative and quantitative analysis of core loading, structural integrity, and long-term stability. This review systematically examines current characterization techniques ranging from morphological evaluation and quantitative elemental analysis to advanced spectroscopic and functional performance assays for evaluating metal and non-metal encapsulation efficiency, release kinetics, stability in complex biological media, and functional performance of ferritin-based nanocarriers. We highlight the correlation between the analytical metrics and biomedical outcomes, addressing the critical challenges in standardization necessary for clinical translation. The discussed methodologies establish a methodological roadmap for the rational design and quality control of ferritin-based theranostic systems, facilitating their path toward clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Scientific Center for Translational Medicine, Sirius University of Science and Technology, 354340 Sirius, Russia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elena N. Subcheva",
      "orcid": "0009-0006-9282-3582"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandra A. Martynova"
    },
    {
      "affs": [
        0
      ],
      "name": "Darya S. Volkova",
      "orcid": "0009-0008-6495-0474"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrey V. Zvyagin",
      "orcid": "0000-0001-8799-2257"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessandro Parodi",
      "orcid": "0000-0003-0985-6545"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexey V. Ermakov",
      "orcid": "0000-0001-8105-5932"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fmahpzg4er9tj.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209383",
  "fulltext_url": null,
  "id": "fmahpzg4er9tj",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9383",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7223406269",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/fmahpzg4er9tj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209383",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9383"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Ferritin-Based Nanocarriers: Analytical Methods for Physicochemical Characterization",
  "title_text": "Ferritin-Based Nanocarriers: Analytical Methods for Physicochemical Characterization",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:57Z",
  "url": "https://research.draconitic.com/paper/fmahpzg4er9tj",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}