{
  "abstract": "The title compounds, (RO)(NHR')P(O)H, were synthesized earlier from P-chloro intermediates by substitutions or from dialkyl phosphites by reaction with organometallic reagents. Instead of these not clear-cut and not efficient transformations, a green, solvent- and catalyst-free synthesis of alkyl phosphonamidates has been developed by the microwave-assisted aminolysis of dialkyl phosphites. The monosubstitution was fully selective. Under more forcing conditions, an interesting side reaction was observed. The resulting products may be valuable reagents to prepare α-hydroxy- and α-aminophosphonic derivatives.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, 1111Budapest, Hungary."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zsuzsanna Szalai",
      "orcid": "0009-0002-3559-6011"
    },
    {
      "affs": [
        0
      ],
      "name": "Anna Sára Kis"
    },
    {
      "affs": [
        0
      ],
      "name": "Péter Keglevich"
    },
    {
      "affs": [
        0
      ],
      "name": "György Keglevich",
      "orcid": "0000-0002-5366-472X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fmcgr81mwjas0.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03484",
  "fulltext_url": "https://europepmc.org/articles/PMC13595902",
  "id": "fmcgr81mwjas0",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42918090",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organophosphorus compounds synthesis"
    ]
  ],
  "openalex": "W7212032597",
  "pdf_url": "https://europepmc.org/articles/PMC13595902?pdf=render",
  "pmcid": "PMC13595902",
  "pmid": "42918090",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fmcgr81mwjas0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42918090",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42918090"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organophosphorus compounds synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Preparation of Alkyl N-Alkylphosphonamidates by the Microwave-Assisted Selective Monoaminolysis of Dialkyl Phosphites.",
  "title_text": "Preparation of Alkyl N-Alkylphosphonamidates by the Microwave-Assisted Selective Monoaminolysis of Dialkyl Phosphites.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/fmcgr81mwjas0",
  "venue": "Organic letters",
  "versions": []
}