{
  "abstract": "Polymeric nanoparticles have emerged as versatile platforms for modern drug delivery, offering improved therapeutic outcomes through controlled release, enhanced absorption, and targeted action. Recent developments in fabrication techniques such as nanoprecipitation, emulsion polymerization, and free radical polymerization have enabled precise control over nanoparticle design, size, and functionality. Advances in stimuli-responsive systems, including pH-, temperature-, and light-sensitive polymers, as well as multifunctional nanocarriers, have further enhanced therapeutic accuracy. Applications extend to cancer therapy, where solubility and tumor targeting are improved; gene therapy, where nucleic acid delivery is optimized; and biologics delivery, where encapsulation enhances stability. Additionally, antimicrobial and antiviral uses highlight their potential against infections. Despite these achievements, challenges persist in regulating toxicity, clearance, biodistribution, and immunogenicity. This review underscores both the promise and the limitations of polymeric nanoparticles, emphasizing their transformative potential while identifying the barriers that must be addressed for successful clinical translation.",
  "abstract_shown": true,
  "affiliations": [
    "Natural Product and Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Jammu 180001, India",
    "Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Uttarakhand 247 667, India",
    "Department of Bioinformatics, University of North Bengal, District-, Darjeeling, West Bengal 734 013, India",
    "Department of Chemistry, RTM Nagpur University, Nagpur 440 033, India",
    "Chemistry Department, Faculty of Science, Applied Science Private University, P.O. Box 166, Amman 11931, Jordan",
    "College of Natural and Computational Sciences, Chemistry Department, University of Gondar, P.o.box, 196,Gondar, Ethiopia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sumeer Ahmed",
      "orcid": "0000-0001-8625-9504"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohd Hasan Mujahid",
      "orcid": "0000-0003-3115-7855"
    },
    {
      "affs": [
        0
      ],
      "name": "Mandeep Kour"
    },
    {
      "affs": [
        1
      ],
      "name": "Shaista Fatima",
      "orcid": "0009-0005-9764-9301"
    },
    {
      "affs": [
        1
      ],
      "name": "Salaman Ahamad",
      "orcid": "0009-0007-9359-8513"
    },
    {
      "affs": [
        2
      ],
      "name": "Saurav Kumar Mishra",
      "orcid": "0009-0002-8154-6816"
    },
    {
      "affs": [
        3
      ],
      "name": "Ajmal Rashid Bhat",
      "orcid": "0000-0003-4751-8379"
    },
    {
      "affs": [
        4
      ],
      "name": "Ahmed Abu‐Rayyan",
      "orcid": "0000-0002-6520-1626"
    },
    {
      "affs": [
        5
      ],
      "name": "Birhanu Ayalew Tebeje",
      "orcid": "0000-0002-4171-1429"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fmqd96bx03s5p.bib",
  "cited_by": 12,
  "doi": "10.1016/j.rechem.2026.103459",
  "fulltext_url": null,
  "id": "fmqd96bx03s5p",
  "issns": [
    "2211-7156"
  ],
  "landing_url": "https://doi.org/10.1016/j.rechem.2026.103459",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7162865902",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-30",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/fmqd96bx03s5p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:27:00Z",
      "native_id": "W7162865902",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.rechem.2026.103459"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Molecular design and therapeutic applications of polymeric nanoparticles for drug delivery: A comprehensive review",
  "title_text": "Molecular design and therapeutic applications of polymeric nanoparticles for drug delivery: A comprehensive review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:22Z",
  "url": "https://research.draconitic.com/paper/fmqd96bx03s5p",
  "venue": "Results in Chemistry",
  "versions": []
}