{
  "abstract": "Therapy resistance in glioblastoma is usually described in genetic or metabolic terms. Here we ask whether it also has a measurable biophysical form. Combining Raman spectroscopy with scanning acoustic microscopy on TRAIL-sensitive and TRAIL-resistant glioblastoma cells, we find that resistance carries both a biochemical and a mechanical signature: the resistant cells differ at protein, lipid and nucleic-acid bands, contain 4.1-fold more neutral lipid, and hold a high acoustic impedance that does not change when the drug is applied, while sensitive cells stiffen as they die. Because acoustic impedance is an absolute quantity and neither measurement requires a label, the approach offers a route to recognising resistant populations from their physical state alone.",
  "abstract_shown": true,
  "affiliations": [
    "Bogazici University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "T. Pesen"
    },
    {
      "name": "A. Inanc"
    },
    {
      "name": "D. Inci"
    },
    {
      "name": "A. Cingoz"
    },
    {
      "name": "B. Akgun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fn6eme1mw9d9w.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.14.759182",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759182v1.full",
  "id": "fn6eme1mw9d9w",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759182v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biophysics"
    ],
    [
      "openalex",
      "1304|Spectroscopy Techniques in Biomedical and Chemical Research"
    ]
  ],
  "openalex": "W7222579656",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759182v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fn6eme1mw9d9w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:05Z",
      "native_id": "10.64898/2026.10.14.759182",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759182v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biophysics",
      "subfield": "biophysics"
    }
  ],
  "title": "Coupling Raman Spectroscopy and Acoustic Microscopy to Characterize Glioblastoma Resistance",
  "title_text": "Coupling Raman Spectroscopy and Acoustic Microscopy to Characterize Glioblastoma Resistance",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:05Z",
  "url": "https://research.draconitic.com/paper/fn6eme1mw9d9w",
  "venue": "bioRxiv",
  "versions": []
}