{
  "abstract": "Pithecellobium eriorhachis Harms . (Fabaceae) has been used as a folk medicine to treat various diseases in Cameroon and other countries. The present study aimed to isolate and characterise compounds with cytotoxic activity against three glioblastoma cancer cell lines (U87-MG, U251-MG, LN229) from the stem bark of P. eriorachis . As a result, two new cerebrosides, trivially named Pithecellobioside A and B ( 1–2 ), together with seven known compounds, were isolated by silica gel column chromatography, including one alkaloid ( 3 ), four flavonoids ( 4–7 ) and two steroids ( 8–9 ). The structures of all isolated compounds were elucidated using extensive spectral data, including 1D and 2D NMR, HR-ESI-MS, and comparison of their NMR data with those of previously reported compounds. Both new compounds ( 1 – 2 ) were assessed in vitro using the MTT assay on three glioblastoma cancer cell lines (U87-MG, U251-MG, and LN229). U87-MG cells were the most sensitive to compound 1 (IC 50 = 1.23 ± 0.06 μg/mL), while compound 2 showed the highest activity against LN229 cells (IC 50 = 2.68 ± 0.08 μg/mL), exceeding that of the reference drug (oxaliplatin against LN229, IC 50 = 4.78 ± 0.56 μg/mL). Pithecellobioside B ( 2 ) is identified as a potent cytotoxic compound that warrants further investigation for the development of novel antiproliferative drugs targeting LN229 epithelial-like glioblastoma cells. These findings indicate that Pithecellobiosides A and B ( 1–2 ) represent new cerebrosides with selective cytotoxicity against glioblastoma cells, highlighting P. eriorachis as a promising source of bioactive glycosphingolipids.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Raduis Melong"
    },
    {
      "name": "Steven Collins Njonte Wouamba"
    },
    {
      "name": "Armelle Tsamo Tontsa"
    },
    {
      "name": "Jean Paul Dzoyem"
    },
    {
      "name": "Éric Allémann"
    },
    {
      "name": "Florence Delie"
    },
    {
      "name": "Michel Gelbcke"
    },
    {
      "name": "Franck Meyer"
    },
    {
      "name": "Gilbert Deccaux Wabo Fotso Kapche"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fn8vkwqfn2ye7.bib",
  "cited_by": 0,
  "doi": "10.1016/j.fitote.2026.107248",
  "fulltext_url": null,
  "id": "fn8vkwqfn2ye7",
  "issns": [
    "0367-326X",
    "1873-6971"
  ],
  "landing_url": "https://hal.science/hal-05790557v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Phytochemical Studies and Bioactivities"
    ]
  ],
  "openalex": "W7153990956",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/fn8vkwqfn2ye7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "hal-05790557",
      "source": "hal",
      "url": "https://hal.science/hal-05790557v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Phytochemical Studies and Bioactivities",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Isolation and characterization of two new cytotoxic glycosylsphingolipids from the stem bark of Pithecellobium eriorhachis Harms. (Fabaceae)",
  "title_text": "Isolation and characterization of two new cytotoxic glycosylsphingolipids from the stem bark of Pithecellobium eriorhachis Harms. (Fabaceae)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/fn8vkwqfn2ye7",
  "venue": "Fitoterapia",
  "versions": []
}