{
  "abstract": "As cosmetic procedures gain popularity, the use of nonapproved soft-tissue fillers by unlicensed or untrained practitioners in nonmedical settings is rising. We report a rare case of a histiocytic reaction to foreign material following Argiform injection. A 31-year-old female presented with a 2 year history of an itchy and painful rash on both buttocks. The rash was initially confined to the right buttock but extended to the left several months later; it remained refractory to topical ointments. A skin punch biopsy revealed extensive adipocytic-like cells within the dermis, some of which mimicked lipoblasts. Immunohistochemistry showed the lesional cells were positive for CD68 and negative for S100 and pancytokeratin. A final diagnosis of a histiocytic reaction to foreign material was made. Following the biopsy results, the patient disclosed a history of cosmetic Argiform injections at a spa 4-5 years prior to presentation. This case demonstrates that delayed tissue reactions to Argiform can mimic lipomatous tumors, creating a significant diagnostic pitfall. Clinicopathologic correlation, including a thorough remote medical history, is critical for achieving an accurate diagnosis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology & Immunology Baylor College of Medicine Houston 77030 Texas USA bcm.edu.",
    "Department of Dermatology Baylor College of Medicine Houston 77030 Texas USA bcm.edu.",
    "Department of Pathology & Laboratory Medicine Harris Health System Ben Taub Hospital Houston 77030 Texas USA.",
    "Department of Surgery Pathology Service HCA Houston Healthcare Clear Lake Webster 77598 Texas USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mokhtar H Abdelhammed",
      "orcid": "0009-0001-9607-683X"
    },
    {
      "affs": [
        0
      ],
      "name": "Lois M Dodson"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "A Hafeez Diwan"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Ya Xu",
      "orcid": "0000-0002-4073-8443"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fngwxq70jfcqz.bib",
  "cited_by": 0,
  "doi": "10.1155/crdm/7330965",
  "fulltext_url": "https://europepmc.org/articles/PMC13680846",
  "id": "fngwxq70jfcqz",
  "issns": [
    "2090-6463",
    "2090-6471"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903457",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Facial Rejuvenation and Surgery Techniques"
    ]
  ],
  "openalex": "W7223027502",
  "pdf_url": "https://europepmc.org/articles/PMC13680846?pdf=render",
  "pmcid": "PMC13680846",
  "pmid": "42903457",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fngwxq70jfcqz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903457",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903457"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Facial Rejuvenation and Surgery Techniques",
      "subfield": "general"
    }
  ],
  "title": "Delayed Histiocytic Foreign Body Reaction and Granuloma Formation Following Argiform Injection for Soft Tissue Augmentation Mimicking a Lipomatous Tumor on Histopathology: A Case Report.",
  "title_text": "Delayed Histiocytic Foreign Body Reaction and Granuloma Formation Following Argiform Injection for Soft Tissue Augmentation Mimicking a Lipomatous Tumor on Histopathology: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/fngwxq70jfcqz",
  "venue": "Case reports in dermatological medicine",
  "versions": []
}