{
  "abstract": "This review examines the expanding role of PARP inhibitors in cancer therapy, moving beyond the traditional model of single-strand break repair inhibition and BRCA-dependent synthetic lethality. We highlight emerging evidence that PARP inhibitors induce cytotoxicity through replication-associated DNA damage, including defects in Okazaki fragment maturation and replication gap accumulation. By integrating recent mechanistic insights with findings from CRISPR-based screens, we outline how disruptions in DNA replication and repair pathways define a broader BRCAness phenotype. We further emphasize the clinical implications of these discoveries, including novel combination strategies that extend the therapeutic applicability of PARP inhibitors beyond prevailing treatment regimens.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Anthony Fernandez"
    },
    {
      "name": "Yuvika Salman",
      "orcid": "0009-0005-2689-7308"
    },
    {
      "name": "Roxanne Castillo"
    },
    {
      "name": "Carlotta Glackin"
    },
    {
      "name": "Binghui Shen",
      "orcid": "0000-0002-4408-407X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fpbtcr88svy1w.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11257-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13728100",
  "id": "fpbtcr88svy1w",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11257-x",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.nature.com/articles/s42003-026-11257-x.pdf",
  "pmcid": "PMC13728100",
  "pmid": "42972010",
  "published": "2026-11-02",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/fpbtcr88svy1w.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T18:20:52Z",
      "native_id": "10.1038/s42003-026-11257-x",
      "source": "feed-nature",
      "url": "https://www.nature.com/articles/s42003-026-11257-x"
    },
    {
      "first_seen": "2026-11-03T00:20:50Z",
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      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11257-x"
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    {
      "first_seen": "2026-11-04T15:20:43Z",
      "native_id": "MED:42972010",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972010"
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    {
      "first_seen": "2026-11-06T12:23:50Z",
      "native_id": "PMC13728100",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s42003-026-11257-x"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Widening the BRCAness therapeutic window for its synthetic lethality effects with PARP inhibitors",
  "title_text": "Widening the BRCAness therapeutic window for its synthetic lethality effects with PARP inhibitors",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:09Z",
  "url": "https://research.draconitic.com/paper/fpbtcr88svy1w",
  "venue": "Communications Biology",
  "versions": []
}