{
  "abstract": "Preeclampsia is a pregnancy disorder with often severe consequences across the maternal-fetal dyad and limited treatment options. We performed an integrated meta-analysis of six placental transcriptomic datasets to identify a preeclampsia-specific gene expression signature, revealing dysregulated pathways related to hypoxia, immune dysfunction, and metabolism. Multivariate INTegrative (MINT) analysis was used to establish a smaller predictive signature with potential utility for identifying circulating biomarkers for earlier preeclampsia diagnosis and monitoring disease progression. This preeclampsia signature queried against a transcriptomic database of more than 1,000 compounds identified lansoprazole, a widely used proton pump inhibitor with an established safety profile, as the top-ranked compound based on its ability to reverse the preeclampsia-associated gene expression signature. Protective benefits of lansoprazole were confirmed using a murine model of immune-mediated fetal wastage where treatment overturned elevated soluble FLT1 levels with significantly improved pregnancy outcomes. These findings support further investigation of lansoprazole as a potential therapy for preeclampsia.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Romina Appierdo"
    },
    {
      "name": "Giang Pham"
    },
    {
      "name": "Ophelia Yin"
    },
    {
      "name": "Alice S. Tang"
    },
    {
      "name": "Tzu-yu Shao"
    },
    {
      "name": "Ashley L. Severance"
    },
    {
      "name": "Bahar Yilmaz"
    },
    {
      "name": "Jakob Einhaus"
    },
    {
      "name": "Ronald J. Wong"
    },
    {
      "name": "Francesco Vallania"
    },
    {
      "name": "Pier Federico Gherardini"
    },
    {
      "name": "Manuela Helmer-Citterich"
    },
    {
      "name": "Brice Gaudillière"
    },
    {
      "name": "Tomiko T. Oskotsky"
    },
    {
      "name": "David K. Stevenson"
    },
    {
      "name": "Sing Sing Way"
    },
    {
      "name": "Marina Sirota"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fpd8jy7rehf98.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117963",
  "fulltext_url": "https://europepmc.org/articles/PMC13743939",
  "id": "fpd8jy7rehf98",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03346-8",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Pregnancy"
    ],
    [
      "heading",
      "Systems biology"
    ],
    [
      "heading",
      "Transcriptomics"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13743939?pdf=render",
  "pmcid": "PMC13743939",
  "pmid": "42999525",
  "published": "2026-10-30",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/fpd8jy7rehf98.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:20:54Z",
      "native_id": "10.1016/j.isci.2026.117963",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03346-8"
    },
    {
      "first_seen": "2026-10-31T12:20:57Z",
      "native_id": "10.1016/j.isci.2026.117963",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226033468"
    },
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42999525",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999525"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Systems biology",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Integrative transcriptomic analysis and preclinical validation identify lansoprazole as a therapeutic candidate for preeclampsia",
  "title_text": "Integrative transcriptomic analysis and preclinical validation identify lansoprazole as a therapeutic candidate for preeclampsia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/fpd8jy7rehf98",
  "venue": "iScience",
  "versions": []
}