{
  "abstract": "Background\n\nEarly medication nonadherence represents a critical barrier to achieving optimal outcomes in major depressive disorder (MDD). Despite India's high depression burden, only a few studies have examined psychosocial factors associated with early nonadherence in routine clinical settings.Aim\n\nTo evaluate the prevalence and psychosocial factors associated with early self-reported medication nonadherence in depression within 1 month of treatment in a psychiatric outpatient department.Methods\n\nA prospective cohort study included 101 adults diagnosed with MDD at a tertiary hospital in Northeast India who were antidepressant-naïve for the current episode and attended their first follow-up within a month. Sociodemographic and clinical factors, depression severity, and stigma were assessed at baseline. Medication adherence and medication attitudes were assessed at follow-up.Results\n\nEarly self-reported medication nonadherence occurred in 27.7% of patients. In bivariate analysis, nonadherence was associated with longer episode duration, treatment-emergent side effects, higher personal and perceived stigma, and poorer medication attitudes. In logistic regression, higher perceived stigma was associated with increased odds of early medication nonadherence (OR = 1.31, 95% CI: 1.04 to 1.67, P = .015) and higher drug attitude scores were associated with lower odds (OR = 0.76, 95% CI: 0.64 to 0.90, P < .001), whereas sociodemographic variables did not show a significant association.Conclusion\n\nNearly one-third of MDD patients self-reported early medication nonadherence. Psychosocial determinants, particularly stigma and negative medication attitudes, played a greater role than demographic or clinical factors. Early psychoeducation and stigma-reduction strategies could be crucial for enhancing medication adherence and improving treatment outcomes in depression.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry, Max Multi-Speciality Hospital, Lucknow, Uttar Pradesh, India.",
    "Department of Psychiatry, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok, Sikkim, India."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Apoorva Upadhyay"
    },
    {
      "affs": [
        1
      ],
      "name": "Geeta Soohinda"
    },
    {
      "affs": [
        1
      ],
      "name": "Harshavardhan Sampath"
    },
    {
      "affs": [
        1
      ],
      "name": "Sanjiba Dutta"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fpsk69k1nfa1x.bib",
  "cited_by": 0,
  "doi": "10.4103/indianjpsychiatry_1083_25",
  "fulltext_url": "https://europepmc.org/articles/PMC13750501",
  "id": "fpsk69k1nfa1x",
  "issns": [
    "0019-5545",
    "1998-3794"
  ],
  "landing_url": "https://europepmc.org/article/MED/43011926",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2714|Medication Adherence and Compliance"
    ]
  ],
  "openalex": "W7223120577",
  "pdf_url": "https://europepmc.org/articles/PMC13750501?pdf=render",
  "pmcid": "PMC13750501",
  "pmid": "43011926",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fpsk69k1nfa1x.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:25:13Z",
      "native_id": "MED:43011926",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43011926"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2714|Medication Adherence and Compliance",
      "subfield": "general"
    }
  ],
  "title": "Early self-reported medication non-adherence in depression: A hospital-based prospective study from Northeast India.",
  "title_text": "Early self-reported medication non-adherence in depression: A hospital-based prospective study from Northeast India.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:21:10Z",
  "url": "https://research.draconitic.com/paper/fpsk69k1nfa1x",
  "venue": "Indian journal of psychiatry",
  "versions": []
}