{
  "abstract": "Objectives: To evaluate whether bedside bioimpedance analysis and simple functional tests can identify muscle function impairment associated with overall survival in chemotherapy-treated metastatic urothelial carcinoma.\n\nMaterials: Retrospective single-center observational cohort study.\n\nMethods: We reviewed 56 consecutive patients treated with systemic chemotherapy between January 2014 and February 2021. Skeletal muscle index was estimated using bioimpedance analysis. Handgrip strength and walking speed were assessed in routine care. Sarcopenia-related categories were defined using sex-specific Asian Working Group for Sarcopenia thresholds. The prespecified primary comparison was reference (normal plus pre-sarcopenia) versus muscle function impairment (dynapenia plus sarcopenia). Overall survival was evaluated using Kaplan-Meier analysis and Cox models with minimal age adjustment.\n\nResults: Muscle function impairment was associated with shorter overall survival compared with the reference group. The association remained after age adjustment. Baseline characteristics suggested greater vulnerability in the impairment group, including lower body weight and serum albumin and higher inflammatory burden.\n\nConclusions: A pragmatic bedside phenotype based on bioimpedance analysis and simple functional testing may help identify chemotherapy-treated metastatic urothelial carcinoma patients at higher risk of poor survival.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "NOBUHITO MURAMOTO"
    },
    {
      "name": "KOSUKE KITAMURA"
    },
    {
      "name": "TOMOYA SHIRAKAWA"
    },
    {
      "name": "KAZUHIRO FUKUDA"
    },
    {
      "name": "AKIMASA KURE"
    },
    {
      "name": "TOSHIYUKI CHINA"
    },
    {
      "name": "HARUNA KAWANO"
    },
    {
      "name": "SHUJI ISOTANI"
    },
    {
      "name": "SATORU MUTO"
    },
    {
      "name": "HISAMITSU IDE"
    },
    {
      "name": "SHIGEO HORIE"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fq6wnejf054a9.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725222/",
  "id": "fq6wnejf054a9",
  "issns": [
    "2759-7504"
  ],
  "landing_url": "https://europepmc.org/article/MED/42973800",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Articles"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13725222?pdf=render",
  "pmcid": "PMC13725222",
  "pmid": "42973800",
  "published": "2026-09-01",
  "publisher": "Juntendo Medical Society",
  "ris": "https://research.draconitic.com/paper/fq6wnejf054a9.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:39Z",
      "native_id": "PMC13725222",
      "source": "pmc",
      "url": null
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42973800",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973800"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Bedside Bioimpedance and Simple Functional Tests Identify Muscle Function Impairment Predicting Overall Survival in Chemotherapy-treated Metastatic Urothelial Carcinoma: A Retrospective Pilot Study",
  "title_text": "Bedside Bioimpedance and Simple Functional Tests Identify Muscle Function Impairment Predicting Overall Survival in Chemotherapy-treated Metastatic Urothelial Carcinoma: A Retrospective Pilot Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:32Z",
  "url": "https://research.draconitic.com/paper/fq6wnejf054a9",
  "venue": "Juntendo Medical Journal",
  "versions": []
}