{
  "abstract": "Pneumoviruses cause seasonal outbreaks leading to hospitalizations of vulnerable populations such as infants and the elderly. Cross-neutralizing antibodies targeting viral fusion have been isolated from infected individuals, but their elicitation and mechanisms of action remain understudied. Here, we describe two vaccine-elicited antibody classes, LOR24 and LOR69, that bind an overlapping epitope, and identify the somatic mutations that endow their breadth and potency, respectively. Cryo-electron microscopy structures of both antibodies bound to the HRSV fusion (F) protein show binding modes distinct from each other and from the previously described cross-neutralizing antibody MPE8, yet they all use similar motifs for binding. Complementary in vitro and electron microscopy experiments show that these antibodies either lock prefusion F as a trimer, arrest F in a monomeric or intermediate state, or promote the transition to the postfusion conformation. This work sheds light on mechanisms of pneumovirus neutralization and the elicitation of cross-neutralizing antibody responses.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Cent"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. Ols"
    },
    {
      "name": "R. Arcoverde Cerveira"
    },
    {
      "name": "A. J. Borst"
    },
    {
      "name": "E. Bermudez-Mendez"
    },
    {
      "name": "F. Gegenfurtner"
    },
    {
      "name": "E. Eray"
    },
    {
      "name": "C. Weidle"
    },
    {
      "name": "M. C. Miranda"
    },
    {
      "name": "Z. Peng"
    },
    {
      "name": "K. D. Carr"
    },
    {
      "name": "R. Skotheim"
    },
    {
      "name": "J. Kochmann"
    },
    {
      "name": "N. Brunette"
    },
    {
      "name": "K. Lenart"
    },
    {
      "name": "L. Hanke"
    },
    {
      "name": "G. B. Karlsson Hedestam"
    },
    {
      "name": "L. Perez"
    },
    {
      "name": "A. Antanasijevic"
    },
    {
      "name": "N. P. King"
    },
    {
      "name": "K. Lore"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fq7rqyttrpxsr.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.21.749132",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.749132v1.full",
  "id": "fq7rqyttrpxsr",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.749132v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "openalex",
      "2713|Respiratory viral infections research"
    ]
  ],
  "openalex": "W7214195687",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.749132v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fq7rqyttrpxsr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:20Z",
      "native_id": "10.64898/2026.09.21.749132",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.749132v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Distinct mechanisms of neutralization by antibodies targeting a conserved pneumovirus F epitope",
  "title_text": "Distinct mechanisms of neutralization by antibodies targeting a conserved pneumovirus F epitope",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:20Z",
  "url": "https://research.draconitic.com/paper/fq7rqyttrpxsr",
  "venue": "bioRxiv",
  "versions": []
}