{
  "abstract": "Background: Liquorice, a popular confectionary product, contains several bioactive compounds. Amongst them, glycyrrhizic acid is associated with increased blood pressure, and glabridin is associated with anti-inflammatory and glucose-lowering effects. The aim was to assess the association between short term liquorice intake at a dose known to elevate blood pressure, and markers of dysglycemia, blood lipids, high-sensitivity C-reactive protein (hsCRP), and calcium metabolism. Methods: In a 2x2 crossover study, 28 healthy adults were randomized to consume liquorice or a control product in alternating 2-week periods, with measurements of blood glycated haemoglobin A1c as well as plasma glucose, calcium ion, parathyroid hormone, and lipids at the end of each period. Liquorice glabridin content was determined via LC-MSMS analysis. Results: The liquorice contained 0.25 ± 0.14 µg glabridin per mg. The plasma hsCRP value increased by 32.5% (95% CI −9.7 to 74.6) during the intervention period vs 311.5% (95% CI −40.8 to 663.7) during the control period, P = .045. No effects on the other markers were observed. Conclusion: Liquorice intake did not improve metabolic markers but attenuated hsCRP elevation. The potential metabolic benefits of glabridin are unlikely to outweigh the hypertensive effects when consumed as whole liquorice.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden",
    "Primary Healthcare Center Cityhälsan Centrum, Region Östergötland, Norrköping, Sweden",
    "Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden",
    "Primary Healthcare Center Kärna, Region Östergötland, Linköping, Sweden",
    "The George Institute for Global Health, University of New South Wales, Sydney, Australia"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anna Åstrand"
    },
    {
      "affs": [
        1
      ],
      "name": "Annelie Joelsson"
    },
    {
      "affs": [
        2
      ],
      "name": "Karin Rådholm"
    },
    {
      "affs": [
        3
      ],
      "name": "Fredrik H. Nyström"
    },
    {
      "affs": [
        4
      ],
      "name": "Peder af Geijerstam"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fqeb8qx3c50vh.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0358710",
  "fulltext_url": null,
  "id": "fqeb8qx3c50vh",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0358710",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3004|Pharmacological Effects of Natural Compounds"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Body fluids/Blood"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Body fluids/Blood/Blood plasma"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Hormones/Insulin"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Hormones/Parathyroid hormone"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Lipids/Lipid metabolism"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Metabolism/Lipid metabolism"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/C-reactive proteins"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Hemoglobin/HbA1c"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Body fluids/Blood"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Body fluids/Blood/Blood plasma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Body fluids/Blood"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Body fluids/Blood/Blood plasma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Diabetes diagnosis and management/HbA1c"
    ],
    [
      "plos",
      "/Medicine and health sciences/Endocrinology/Diabetic endocrinology/Insulin"
    ],
    [
      "plos",
      "/Physical sciences/Chemistry/Chemical compounds/Organic compounds/Carbohydrates/Monosaccharides/Glucose"
    ],
    [
      "plos",
      "/Physical sciences/Chemistry/Organic chemistry/Organic compounds/Carbohydrates/Monosaccharides/Glucose"
    ]
  ],
  "openalex": "W7214045521",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0358710&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-22",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/fqeb8qx3c50vh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "10.1371/journal.pone.0358710",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0358710"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Glabridin content and metabolic effects of liquorice confectionaries: A secondary analysis of a randomized crossover trial in young adults",
  "title_text": "Glabridin content and metabolic effects of liquorice confectionaries: A secondary analysis of a randomized crossover trial in young adults",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/fqeb8qx3c50vh",
  "venue": "PLOS One",
  "versions": []
}