{
  "abstract": "Background: The monocyte-to-albumin ratio (MAR) integrates systemic inflammation and nutritional status and has been proposed as a predictor of mortality after spontaneous intracerebral hemorrhage (sICH). However, independent validation in an exclusively elderly cohort remains limited. We aimed to evaluate the association between admission MAR and 30-day mortality in patients aged ≥65 years with sICH.\n\nMethods: This single-center retrospective study included 206 consecutive elderly patients with acute sICH. MAR was calculated as monocyte count (×10 ⁹ /L) divided by serum albumin (g/L). The primary outcome was 30-day all-cause mortality. Optimal MAR cutoff was determined by Youden’s index. Kaplan–Meier and multivariable Cox regression analyses were performed.\n\nResults: 30-day mortality was 38.8%. MAR was significantly higher in non-survivors (0.022 vs. 0.016, p < 0.001). The optimal cutoff was 0.021 (AUC 0.648, 95% CI 0.572–0.724), providing sensitivity of 57.5% and specificity of 68.3%. MAR performance was comparable to the neutrophil-to-lymphocyte ratio (AUC 0.643) and systemic inflammatory response index (AUC 0.637). After adjustment, MAR > 0.021 was independently associated with 30-day mortality (adjusted HR 2.41, 95% CI 1.51–3.85, p < 0.001). In a sensitivity analysis using the ICH score as the primary severity covariate, MAR remained independently associated with mortality (adjusted HR 2.02, 95% CI 1.25–3.26, p = 0.004).\n\nConclusion: Admission MAR is independently associated with 30-day mortality in elderly sICH patients, although its discriminative ability is limited (AUC 0.648). As a simple, routinely available parameter, MAR may serve as a supplementary—not standalone—bedside risk stratification tool.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, Shanxi Provincial People's Hospital , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lihui Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Fenglin Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Keyi Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Haoshuang Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Sujun Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Santao Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fqfrnxbeyb3bd.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1948936",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661444/?tool=EBI",
  "id": "fqfrnxbeyb3bd",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13661444",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Intracerebral and Subarachnoid Hemorrhage Research"
    ]
  ],
  "openalex": "W7214971182",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661444/pdf/?tool=EBI",
  "pmcid": "PMC13661444",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/fqfrnxbeyb3bd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "PMC:PMC13661444",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13661444"
    },
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1948936",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1948936/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracerebral and Subarachnoid Hemorrhage Research",
      "subfield": "neurology"
    }
  ],
  "title": "Predictive value of the monocyte-to-albumin ratio at admission for 30-day mortality in elderly patients with spontaneous intracerebral hemorrhage: a retrospective analysis",
  "title_text": "Predictive value of the monocyte-to-albumin ratio at admission for 30-day mortality in elderly patients with spontaneous intracerebral hemorrhage: a retrospective analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:16Z",
  "url": "https://research.draconitic.com/paper/fqfrnxbeyb3bd",
  "venue": "Frontiers in neurology",
  "versions": []
}