{
  "abstract": "Background: To determine the incidence, risk factors, and outcomes of invasive pulmonary aspergillosis (IPA) in critically ill patients with Influenza A pneumonia in post-COVID-19 China. Methods: We conducted a multicenter retrospective cohort study across 21 ICUs (November 2024-February 2025) including adults with acute respiratory failure due to confirmed severe Influenza A pneumonia. IPA was defined by 2024 FUNDICU criteria. The primary outcome was 60-day all-cause mortality. Results: Among 542 patients, 179 (33.0%) had IPA. Independent risk factors: renal replacement therapy (aOR 1.63), diabetes (aOR 1.79), bacterial co-infection (aOR 1.64), pre-ICU systemic glucocorticoids (aOR 2.13), and ICU steroids (aOR 1.53). Median time from influenza to IPA diagnosis was 2 days. Sixty-day mortality was higher with IPA (47.5% vs 32.0%, P < 0.001), persisting after matching. Among IPA patients, hematologic disorders (aHR 5.31) and higher CRP predicted death. Conclusions: In the post-COVID-19 era, IPA is highly prevalent and lethal in severe influenza, with rapid onset. Protocolized screening and timely diagnostic strategies are urgently needed.",
  "abstract_shown": true,
  "affiliations": [
    "China National Critical Care Quality Control Center, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China; Department of Critical Care Medicine, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China",
    "China National Critical Care Quality Control Center, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China; The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China",
    "Department of Critical Care Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; China National Critical Care Quality Control Center, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China",
    "Department of Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu, China",
    "Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China",
    "Department of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China",
    "Department of Intensive Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China",
    "Department of Critical Care Medicine, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China",
    "Department of Emergency and Critical Care Medicine, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, China",
    "Department of Critical Care Medicine, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu, China",
    "Department of Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China",
    "Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China",
    "China National Critical Care Quality Control Center, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ming Xue"
    },
    {
      "affs": [
        1
      ],
      "name": "Zijing Zhou"
    },
    {
      "affs": [
        2
      ],
      "name": "Yali Chao"
    },
    {
      "affs": [
        3
      ],
      "name": "Jiaqiong Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Jun Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Zhuxi Yu"
    },
    {
      "affs": [
        6
      ],
      "name": "Xiangrong Zuo"
    },
    {
      "affs": [
        7
      ],
      "name": "Shujun Zhou"
    },
    {
      "affs": [
        8
      ],
      "name": "Yanli Wang"
    },
    {
      "affs": [
        9
      ],
      "name": "Xuehua Pu"
    },
    {
      "affs": [
        10
      ],
      "name": "Chenliang Sun"
    },
    {
      "affs": [
        11
      ],
      "name": "Jiangquan Yu"
    },
    {
      "name": "Songqiao Liu"
    },
    {
      "affs": [
        12
      ],
      "name": "Jianfeng Xie"
    },
    {
      "name": "Ruiqiang Zheng"
    },
    {
      "name": "Yi Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fqt50exrpbhva.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijid.2026.109089",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1201971226007241",
  "id": "fqt50exrpbhva",
  "issns": [
    "1201-9712",
    "1878-3511"
  ],
  "landing_url": "https://doi.org/10.1016/j.ijid.2026.109089",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC109-216"
    ],
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      "openalex",
      "2725|Antifungal resistance and susceptibility"
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  "openalex": "W7204645151",
  "pdf_url": "https://www.ijidonline.com/article/S1201-9712(26)00724-1/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/fqt50exrpbhva.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:31Z",
      "native_id": "6087749f485c48999e5ae0cefcbf1ae5",
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      "url": "https://doi.org/10.1016/j.ijid.2026.109089"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Antifungal resistance and susceptibility",
      "subfield": "infectious-disease"
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  ],
  "title": "Influenza A-associated pulmonary aspergillosis in critically ill patients in the post-COVID-19 era: a multicenter cohort study from China",
  "title_text": "Influenza A-associated pulmonary aspergillosis in critically ill patients in the post-COVID-19 era: a multicenter cohort study from China",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:31Z",
  "url": "https://research.draconitic.com/paper/fqt50exrpbhva",
  "venue": "International Journal of Infectious Diseases",
  "versions": []
}