{
  "abstract": "Intracranial hypertension is a frequent complication of cerebral venous sinus thrombosis (CVT), posing a risk for permanent visual impairment. However, long-term visual outcomes have not been systematically assessed using objective neuro-ophthalmic measures. We retrospectively evaluated consecutive adults presenting to a single-center tertiary intracranial hypertension clinic between 2019 and 2025 with intracranial hypertension following CVT. Visual outcomes were assessed using best-corrected visual acuity, automated perimetry, and optical coherence tomography measuring global peripapillary retinal nerve fiber layer thickness. Headache phenotype and medication overuse were documented. Nineteen patients (11 female; mean age 33.4 ± 12.1 years) were included, with a mean follow-up of 3.4 ± 2.4 years after diagnosis of CVT-related intracranial hypertension. The transverse sinus was involved in 78.9% of cases, and complete or near-complete recanalization was achieved in 68.4%. Although visual acuity remained normal in most patients (84.2%), 26.3% had severe visual field loss and 15.8% showed retinal nerve fiber layer thinning. Headache persisted in 94.7%, most commonly as tension-type headache (63.2%), and 26.3% fulfilled criteria for medication overuse headache. Despite generally preserved visual acuity, substantial visual field deficits and persistent headache were common in CVT-related intracranial hypertension. These findings support routine neuro-ophthalmic follow-up to facilitate early detection of visual deterioration in CVT-related intracranial hypertension. As this cohort was drawn from a specialized tertiary referral clinic, these findings should be interpreted as hypothesis-generating rather than representative of the broader CVT population.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany",
    "Department of Otorhinolaryngology, Helios Hospital Berlin-Buch, Berlin, Germany",
    "Department of Ophthalmology, Charité – Universitätsmedizin Berlin, Berlin, Germany"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Theresia Knoche"
    },
    {
      "affs": [
        1
      ],
      "name": "Ivo Grueninger"
    },
    {
      "affs": [
        2
      ],
      "name": "Charlotte Pietrock"
    },
    {
      "name": "Zohreh Jami"
    },
    {
      "name": "Leon Alexander Danyel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/frannmbx5xr0x.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0362200",
  "fulltext_url": null,
  "id": "frannmbx5xr0x",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0362200",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Cerebral Venous Sinus Thrombosis"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Perception/Sensory perception/Vision"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Perception/Sensory perception/Vision/Visual acuity"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Sensory perception/Vision"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Sensory perception/Vision/Visual acuity"
    ],
    [
      "plos",
      "/Biology and life sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision"
    ],
    [
      "plos",
      "/Biology and life sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision/Visual acuity"
    ],
    [
      "plos",
      "/Medicine and health sciences/Cardiology/Cardiovascular medicine/Cardiovascular diseases/Coagulation disorders/Thrombosis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Headaches"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Headaches/Migraine"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Headaches/Tension-type headache"
    ],
    [
      "plos",
      "/Medicine and health sciences/Hematology/Blood coagulation/Coagulation disorders/Thrombosis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Cardiovascular diseases/Coagulation disorders/Thrombosis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Ophthalmology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Ophthalmology/Visual impairments"
    ],
    [
      "plos",
      "/Medicine and health sciences/Vascular medicine/Thrombosis"
    ],
    [
      "plos",
      "/Social sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision"
    ],
    [
      "plos",
      "/Social sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision/Visual acuity"
    ]
  ],
  "openalex": "W7225383778",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/frannmbx5xr0x.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:24Z",
      "native_id": "10.1371/journal.pone.0362200",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0362200"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:neuroscience",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "plos:cardiovascular diseases",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Visual outcomes and headache in intracranial hypertension following cerebral venous sinus thrombosis: A retrospective cohort study",
  "title_text": "Visual outcomes and headache in intracranial hypertension following cerebral venous sinus thrombosis: A retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:48Z",
  "url": "https://research.draconitic.com/paper/frannmbx5xr0x",
  "venue": "PLOS One",
  "versions": []
}