{
  "abstract": "Heartbeat and behavior are tightly coordinated during defensive states, yet the neuronal mechanisms linking threat processing to cardiac modulation—and the potential contribution of cardiac dynamics to behavioral output—remain poorly understood. Here, using simultaneous recordings of heartbeat and behavior in tethered Drosophila, we show that mechanical threat triggers locomotion together with rapid cardiac deceleration. We identify two pairs of dopaminergic neurons, termed DA-WED neurons, that mediate this cardiac response. Silencing these neurons markedly attenuates threat-induced cardiac deceleration, whereas optogenetic activation induces cardiac deceleration in the absence of threat. Two-photon calcium imaging further shows that DA-WED neurons are activated by mechanical threat, and manipulating their activity bidirectionally modulates threat-induced locomotion. Linking cardiac dynamics to behavior, direct optogenetic manipulation of cardiomyocytes that quantitatively reproduces threat-evoked cardiac deceleration is accompanied by increased locomotion. Together, these results identify a dopaminergic descending pathway that links threat processing to cardiac modulation and suggest that cardiac dynamics may contribute to shaping defensive behavior.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan",
    "International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Masato Tsuji",
      "orcid": "0000-0001-8181-7968"
    },
    {
      "affs": [
        0
      ],
      "name": "Daisuke Jinkoma"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Uemura"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayako Ogasawara"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kazuo Emoto",
      "orcid": "0000-0003-4194-801X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/frevjs091bhsp.bib",
  "cited_by": 0,
  "doi": "10.7554/elife.111256",
  "fulltext_url": "https://elifesciences.org/articles/111256",
  "id": "frevjs091bhsp",
  "issns": [
    "2050-084X"
  ],
  "landing_url": "https://elifesciences.org/articles/111256",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "elife",
      "neuroscience"
    ],
    [
      "openalex",
      "2804|Neurobiology and Insect Physiology Research"
    ]
  ],
  "openalex": "W7162640439",
  "pdf_url": "https://cdn.elifesciences.org/articles/111256/elife-111256-v1.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "eLife Sciences Publications",
  "ris": "https://research.draconitic.com/paper/frevjs091bhsp.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:47Z",
      "native_id": "111256",
      "source": "elife",
      "url": "https://elifesciences.org/articles/111256"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "elife:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Dopaminergic neurons linking threat processing to cardiac modulation and locomotor responses",
  "title_text": "Dopaminergic neurons linking threat processing to cardiac modulation and locomotor responses",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:29Z",
  "url": "https://research.draconitic.com/paper/frevjs091bhsp",
  "venue": "eLife",
  "versions": []
}