{
  "abstract": "Purpose: Fat accumulation leads to obesity, which increases the risk of cardiovascular diseases. Recent studies have shown that adipose (pro)renin receptor ([P]RR) may play a role in fat accumulation, and we previously reported increased adipose (P)RR expression in growth hormone (GH) deficiency in mice; however, the association between human adipose (P)RR expression and GH deficiency remains unclear.\n\nMethods: In this prospective study, abdominal subcutaneous adipose tissue was collected during pituitary surgery in patients with non-functioning hypothalamic-pituitary masses, and the associations between adipose (P)RR mRNA expression, determined using reverse transcription-polymerase chain reaction, and GH deficiency and other clinical parameters were investigated.\n\nResults: Fifteen patients (5 craniopharyngioma, 4 non-functioning pituitary neuroendocrine tumor, 4 Rathke’s cleft cyst, and 2 other diseases) (mean age, 53 ± 17 years; male sex, 3 [20%]; and mean body mass index [BMI], 24.8 ± 4.3 kg/m2; GH deficiency, 8 [53%]) were included. Adipose (P)RR mRNA expression was significantly higher in patients with GH deficiency (P = 0.009) compared to those without, but was not significantly associated with other pituitary functions. Adipose (P)RR mRNA expression was significantly correlated with BMI (r = 0.526, P = 0.044) and body fat mass (r = 0.728, P = 0.026, n = 9). GH deficiency was significantly associated with (P)RR mRNA after adjustment for obesity (β = 2.257, 95% CI: 0.367–4.417, P = 0.023).\n\nConclusion: Adipose (P)RR expression may be increased in GH deficiency, suggesting the possible role of adipose (P)RR in fat accumulation in GH deficiency.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan",
    "Department of Medicine, Tokyo Women’s Medical University Adachi Medical Center, Tokyo, Japan",
    "Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Noriyoshi Takano",
      "orcid": "0009-0002-6476-0183"
    },
    {
      "affs": [
        0
      ],
      "name": "Yasufumi Seki",
      "orcid": "0000-0002-1950-7704"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuko Inoue"
    },
    {
      "affs": [
        0
      ],
      "name": "Kiyotaka Hirata"
    },
    {
      "affs": [
        0
      ],
      "name": "Daisuke Watanabe",
      "orcid": "0000-0002-6526-829X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Satoshi Morimoto",
      "orcid": "0000-0002-2292-2319"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuichi Oda",
      "orcid": "0009-0006-3294-6812"
    },
    {
      "affs": [
        2
      ],
      "name": "Kosaku Amano",
      "orcid": "0000-0002-5589-4852"
    },
    {
      "affs": [
        2
      ],
      "name": "Takakazu Kawamata",
      "orcid": "0000-0002-6076-7065"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsuhiro Ichihara",
      "orcid": "0000-0002-3872-9767"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/frn1nj0fwh5g1.bib",
  "cited_by": 0,
  "doi": "10.1007/s40618-026-02983-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722755/",
  "id": "frn1nj0fwh5g1",
  "issns": [
    "0391-4097",
    "1720-8386"
  ],
  "landing_url": "https://doi.org/10.1007/s40618-026-02983-4",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2712|Growth Hormone and Insulin-like Growth Factors"
    ]
  ],
  "openalex": "W7168840905",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s40618-026-02983-4.pdf",
  "pmcid": "PMC13722755",
  "pmid": "42461577",
  "published": "2026-07-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/frn1nj0fwh5g1.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:31Z",
      "native_id": "PMC13722755",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s40618-026-02983-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Growth Hormone and Insulin-like Growth Factors",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with non-functioning hypothalamic-pituitary masses",
  "title_text": "Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with non-functioning hypothalamic-pituitary masses",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:31Z",
  "url": "https://research.draconitic.com/paper/frn1nj0fwh5g1",
  "venue": "Journal of Endocrinological Investigation",
  "versions": []
}