{
  "abstract": "IIH has evolved into a multidisciplinary condition managed across neurology, ophthalmology, interventional neuroradiology, and surgery. Existing tools address only partial aspects of disease severity; no unified, treatment-oriented classification exists to support multidisciplinary decision-making. Cross-specialty communication is inconsistent leading to heterogenous therapeutic decisions. We aimed to develop and evaluate a standardized multidisciplinary score for idiopathic intracranial hypertension (IIH) and assess its association with therapeutic escalation. We enrolled adults fulfilling the revised Friedman criteria at a tertiary interventional neuroradiology referral center from 2020 to 2025. Clinical data were organized into four domains: ophthalmologic severity with a combination of visual function and tomographic data (E grades 1–4), neuroradiology findings (N grade A to C), intracranial pressure (ICP), and treatment modality. We included 250 patients (93.0% female, median age at diagnosis 29.0 years, median ICP 34.0 cmH 2 O). E grade was significantly associated with invasive intervention ( p < 0.001 for endovascular stenting, Cochran-Armitage test for trend). Among E1-grade patients, 64% underwent endovascular stenting and 64% received high-dose methylprednisolone. Firth’s penalized logistic regression confirmed E grade as a significant independent predictor of invasive interventions (adjusted odds ratio = 0.47 per grade [toward milder disease]; 95% CI 0.32–0.68, p < 0.001). Inter-rater agreement for E grading was substantial (weighted Cohen’s κ 0.82, 95% CI 0.68–0.96). The Combined Idiopathic Intracranial Hypertension score provides a shared, notation for multidisciplinary IIH documentation. In this cohort, the ophthalmologic grade and intracranial pressure were associated with the need for invasive intervention (adjusted OR 0.47 per grade toward milder disease; AUC 0.68), and E grading showed substantial inter-rater agreement (weighted κ 0.82). Prospective external validation is required before the complete four-domain score can be recommended for clinical decision-making. Not applicable.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Max Villain"
    },
    {
      "name": "Marie Latypov"
    },
    {
      "name": "Eloi Debourdeau"
    },
    {
      "name": "Pierre Meyer"
    },
    {
      "name": "Audrey de Jong"
    },
    {
      "name": "Valentin Favier"
    },
    {
      "name": "Florent Fuchs"
    },
    {
      "name": "Luc Jeanjean"
    },
    {
      "name": "Cyril Dargazanli"
    },
    {
      "name": "Chloé Chamard"
    },
    {
      "name": "Anne Ducros"
    },
    {
      "name": "Frédéric Michon"
    },
    {
      "name": "Vincent Costalat"
    },
    {
      "name": "Vincent Daïen"
    },
    {
      "name": "Federico Cagnazzo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fs5czxe8genv8.bib",
  "cited_by": 0,
  "doi": "10.1186/s10194-026-02501-0",
  "fulltext_url": null,
  "id": "fs5czxe8genv8",
  "issns": [
    "1129-2369",
    "1129-2377"
  ],
  "landing_url": "https://hal.science/hal-05755540v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2728|Cerebral Venous Sinus Thrombosis"
    ]
  ],
  "openalex": "W7211986978",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-09",
  "publisher": "SpringerOpen",
  "ris": "https://research.draconitic.com/paper/fs5czxe8genv8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-05755540",
      "source": "hal",
      "url": "https://hal.science/hal-05755540v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Cerebral Venous Sinus Thrombosis",
      "subfield": "neurology"
    }
  ],
  "title": "Combined Idiopathic Intracranial Hypertension score, an integrated severity and treatment-oriented tool for idiopathic intracranial hypertension: a retrospective cohort study",
  "title_text": "Combined Idiopathic Intracranial Hypertension score, an integrated severity and treatment-oriented tool for idiopathic intracranial hypertension: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/fs5czxe8genv8",
  "venue": "Journal of Headache and Pain",
  "versions": []
}