{
  "abstract": "Background: Hypertension is a leading cause of cardiovascular disease and all-cause mortality. In addition, owing to the pathological processes it causes in the vascular bed, it leads to end-organ damage, thereby contributing to morbidity. FABP3 (fatty acid binding protein 3) is a protein primarily expressed in the cardiac muscle, skeletal muscle, and kidney, and plays an important role in cardiomyocyte homeostasis.\n\nMethods: Echocardiographic evaluation was performed in 41 normotensive controls and 120 patients with hypertension. Patients with cardiac remodelling (n = 50) and hypertrophy (n = 33) were identified by calculating the left ventricular mass and relative wall thickness. FABP3 levels were measured in serum samples using ELISA.\n\nResults: FABP3 levels demonstrated an increasing trend (p < 0.0001) across the control, non-remodelled hypertensive, remodelling, and hypertrophy groups (1.27 ± 0.81, 1.85 ± 0.75, 2.31 ± 1.06, and 2.85 ± 1.71 ng/ml, respectively). FABP3 levels were significantly but weakly correlated with posterior wall thickness (ρ = 0.29), relative wall thickness (ρ = 0.23), and troponin levels (ρ = 0.2).\n\nConclusion: These findings suggest that FABP3 may be associated with hypertension-mediated cardiac remodelling and left ventricular hypertrophy. FABP3 may have potential as a supportive biomarker reflecting subclinical cardiac involvement in patients with hypertension.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Biochemistry, Niğde Omer Halisdemir University Training and Research Hospital, Niğde, Türkiye",
    "Department of Cardiology, Niğde Omer Halisdemir University Training and Research Hospital, Niğde, Türkiye",
    "Department of Cardiology, Necmettin Erbakan University, Konya, Türkiye"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meltem Uyaner Kan",
      "orcid": "0000-0002-9478-578X"
    },
    {
      "affs": [
        1
      ],
      "name": "Hasan Kan"
    },
    {
      "affs": [
        2
      ],
      "name": "Sefa Tatar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fsemmwm9nqc2w.bib",
  "cited_by": 0,
  "doi": "10.1186/s12872-026-06439-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741640/",
  "id": "fsemmwm9nqc2w",
  "issns": [
    "1471-2261"
  ],
  "landing_url": "https://doi.org/10.1186/s12872-026-06439-8",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2705|Cardiac Fibrosis and Remodeling"
    ]
  ],
  "openalex": "W7201999698",
  "pdf_url": null,
  "pmcid": "PMC13741640",
  "pmid": "42989129",
  "published": "2026-08-08",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/fsemmwm9nqc2w.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:22:39Z",
      "native_id": "PMC13741640",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12872-026-06439-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Fibrosis and Remodeling",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Evaluation of the relationship between cardiac remodeling and serum FABP3 in hypertensive patients",
  "title_text": "Evaluation of the relationship between cardiac remodeling and serum FABP3 in hypertensive patients",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:22:39Z",
  "url": "https://research.draconitic.com/paper/fsemmwm9nqc2w",
  "venue": "BMC Cardiovascular Disorders",
  "versions": []
}