{
  "abstract": "Neuromedin U (NMU) is a highly conserved neuropeptide involved in the regulation of appetite, energy homeostasis, and neuroendocrine functions. Although the anorexigenic effects of NMU have been demonstrated in both mammals and birds, the neurotransmitter pathways mediating these effects in poultry remain poorly understood. This study investigated the role of dopaminergic and muscarinic receptors in NMU-induced regulation of food intake in broiler chickens. Food-deprived broiler chicks received intracerebroventricular (ICV) injections of NMU and selective antagonists of dopamine (D1–D4) and muscarinic (M1–M4) receptors. Cumulative food intake was measured at 30, 60, and 120 min following treatment, and data were analyzed using repeated-measures two-way ANOVA followed by Duncan’s multiple range test. Central administration of NMU significantly reduced food intake in a dose-dependent manner. Pretreatment with the D1 receptor antagonist SCH23390 and the D2 receptor antagonist AMI-193 significantly attenuated NMU-induced hypophagia, whereas D3 and D4 receptor antagonists failed to modify this response. Similarly, antagonists of M1 (Telenzepine), M2 (AF-DX 116), and M3 (4-DAMP) receptors significantly reversed NMU-induced suppression of feeding, while M4 receptor blockade had no significant effect. These findings indicate that dopaminergic D1 and D2 and muscarinic M1, M2, and M3 receptor systems contribute to the hypophagic response induced by central NMU administration in broiler chicks, whereas blockade of D3, D4, and M4 receptors did not significantly alter this response. These findings provide evidence for receptor subtype-specific involvement in the central regulation of feeding by NMU in avian species and provide a basis for further investigation of the underlying neurochemical mechanisms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Veterinary Basic Sciences, SR.C., Islamic Azad University, Tehran, Iran",
    "Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran",
    "Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Armin Ahmadi"
    },
    {
      "affs": [
        0
      ],
      "name": "Shahin Hassanpour"
    },
    {
      "affs": [
        1
      ],
      "name": "Morteza zendehdel"
    },
    {
      "affs": [
        2
      ],
      "name": "Mohaya Farzin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fsfyjq4ktspv1.bib",
  "cited_by": 0,
  "doi": "10.1016/j.psj.2026.108017",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738116/",
  "id": "fsfyjq4ktspv1",
  "issns": [
    "0032-5791",
    "1525-3171"
  ],
  "landing_url": "https://doi.org/10.1016/j.psj.2026.108017",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full-Length Article"
    ],
    [
      "openalex",
      "2807|Regulation of Appetite and Obesity"
    ]
  ],
  "openalex": "W7223210373",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S0032579126016512/pdf",
  "pmcid": "PMC13738116",
  "pmid": "42950470",
  "published": "2026-10-22",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/fsfyjq4ktspv1.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:09Z",
      "native_id": "PMC13738116",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.psj.2026.108017"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Regulation of Appetite and Obesity",
      "subfield": "physiology"
    }
  ],
  "title": "Dopaminergic and muscarinic receptor involvement in neuromedin U-induced suppression of food intake in broiler chickens",
  "title_text": "Dopaminergic and muscarinic receptor involvement in neuromedin U-induced suppression of food intake in broiler chickens",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:09Z",
  "url": "https://research.draconitic.com/paper/fsfyjq4ktspv1",
  "venue": "Poultry Science",
  "versions": []
}