{
  "abstract": "Aims\n\nHip fracture is a global health issue. Complications are common, leading to reduced quality of life or death. These occur more frequently if anaemia is present. We hypothesize that correcting anaemia in the perioperative period may decrease major adverse cardiac events (MACE) and death after hip fracture.Methods\n\nThis multicentre prospective randomized trial compares transfusion strategies after hip fracture in patients aged ≥ 60 years. We initially planned to randomize 1,984 participants with anaemia, defined as haemoglobin ≤ 90 g l⁻¹, to one of two transfusion strategies: liberal transfusion (aim haemoglobin 90 g l⁻¹ to 110 g l⁻¹), or restrictive transfusion (aim 75 g l⁻¹ to 90 g l⁻¹). The intervention lasts from randomization to hospital discharge or 30 days post randomization, whichever is soonest. The primary outcome measure was a composite of death or MACE adjudicated by blinded clinical experts. Secondary outcomes included all-cause mortality and quality of life, evaluated at 120 days. Cost-effectiveness and health economic evaluation will also be reported.Results\n\nThis trial was funded by the National Institute for Health and Care Research, HTA award (National Institute for Health and Care Research (NIHR) 130875) and registered at ISRCTN 28818784. Ethical approval was obtained to recruit patients in the UK. As recruitment fell short of the initial target, and following consultation with the funder, we refined our primary outcome to include myocardial injury after non-cardiac surgery (MINS), and reduced the required sample size to 842.Conclusion\n\nRecruitment commenced on 10 June 2022. The first participant was recruited on 16 June 2022. We will engage clinicians and healthcare planners to implement the findings. We plan to recruit until 31 October 2026. Results will be disseminated to clinicians, policymakers, patients, and the public.",
  "abstract_shown": true,
  "affiliations": [
    "Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.",
    "Edinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.",
    "Royal Infirmary of Edinburgh, Edinburgh, UK.",
    "The University of Edinburgh, Edinburgh, UK.",
    "ICU Steps, London, UK.",
    "Queen Mary University of London, London, UK.",
    "Oxford Trauma and Emergency Care, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.",
    "Anaesthesia, Injury, Recovery and Inflammation Sciences, School of Medicine, University of Nottingham, Nottingham, UK.",
    "NHS Blood and Transplant and Oxford University Hospitals NHS Foundation Trust, Oxford, UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "name": "RESULT Hip Study Group"
    },
    {
      "affs": [
        0
      ],
      "name": "Rhona C F Sinclair"
    },
    {
      "affs": [
        1
      ],
      "name": "Gayle Beveridge"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Andrew D Duckworth"
    },
    {
      "affs": [
        1
      ],
      "name": "Annabel Giddings"
    },
    {
      "affs": [
        1
      ],
      "name": "Stephanie Cholbi"
    },
    {
      "affs": [
        4
      ],
      "name": "George V Guy"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Sophie Birch"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "David A Hope"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Joanne Singleton"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Lucy Macdonald"
    },
    {
      "affs": [
        1
      ],
      "name": "Catriona Keerie"
    },
    {
      "affs": [
        1
      ],
      "name": "Julia Boyd"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Alixe H M Kilgour"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Alasdair MacLullich"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Annemarie B Docherty"
    },
    {
      "affs": [
        5
      ],
      "name": "Carol Porteous"
    },
    {
      "affs": [
        6
      ],
      "name": "Matthew L Costa"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Nicholas L Mills"
    },
    {
      "affs": [
        7
      ],
      "name": "Iain K Moppett"
    },
    {
      "affs": [
        5
      ],
      "name": "Rupert M Pearse"
    },
    {
      "affs": [
        8
      ],
      "name": "Simon J Stanworth"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrew Stoddart"
    },
    {
      "affs": [
        1
      ],
      "name": "Steff Lewis"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Timothy S Walsh"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Michael A Gillies"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ft0qts5504vz5.bib",
  "cited_by": 0,
  "doi": "10.1302/2633-1462.710.bjo-2026-0131.r1",
  "fulltext_url": "https://europepmc.org/articles/PMC13677165",
  "id": "ft0qts5504vz5",
  "issns": [
    "2633-1462"
  ],
  "landing_url": "https://europepmc.org/article/MED/42893795",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2704|Blood transfusion and management"
    ]
  ],
  "openalex": "W7222864085",
  "pdf_url": "https://europepmc.org/articles/PMC13677165?pdf=render",
  "pmcid": "PMC13677165",
  "pmid": "42893795",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ft0qts5504vz5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42893795",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42893795"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2746|Total Knee Arthroplasty Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "RESULT-Hip. The impact of restrictive compared with liberal transfusion strategy on cardiac injury and death in patients undergoing surgery for hip fracture : protocol for a multicentre, randomized controlled trial of two blood transfusion strategies.",
  "title_text": "RESULT-Hip. The impact of restrictive compared with liberal transfusion strategy on cardiac injury and death in patients undergoing surgery for hip fracture : protocol for a multicentre, randomized controlled trial of two blood transfusion strategies.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/ft0qts5504vz5",
  "venue": "Bone & joint open",
  "versions": []
}