{
  "abstract": "This prospective study evaluated the prognostic utility of Alzheimer’s disease-related plasma biomarkers (phosphorylated tau [pTau217 and pTau231], the amyloid-β [Aβ] 42/40 ratio) and neurofilament light chain (NfL) in 123 Parkinson’s disease (PD) patients and 40 controls. Over a mean 5.1-year follow-up, 35 of 109 initially non-demented PD patients (32.1%) progressed to dementia. Plasma pTau217 and NfL levels were elevated, whereas the Aβ42/40 ratio was reduced, in cognitively impaired PD groups versus controls. Baseline pTau217 accurately differentiated dementia converters from non-converters (AUC = 0.877; 95% CI: 0.798–0.956). Patients with pTau217 ≥ 0.268 pg/mL had a higher risk of dementia progression (HR: 5.49; 95% CI: 2.37–12.74). This risk was further elevated in patients in the highest quartile ( ≥ 0.36 pg/mL; HR: 11.35; 95% CI: 2.60–49.59) versus the lowest quartile ( < 0.20 pg/mL). Similarly, the pTau231 cut-off ( ≥ 2.575 pg/mL) predicted an increased risk of dementia (HR: 3.89; 95% CI: 1.67–9.03). Both pTau217 and pTau231 demonstrated high predictive performance in Cox models (C-index: 0.806 and 0.796, respectively). Plasma NfL exhibited longitudinal increases during follow-up. Baseline plasma pTau217 and pTau231 serve as surrogate markers for predicting dementia progression in PD. Further validation of these biomarker cut-off values is warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan",
    "Department of Neurology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan",
    "Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan",
    "Department of Biomedical Engineering, College of Medical Science and Technology, National Taiwan University, Taipei, Taiwan",
    "Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan",
    "Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Cheng-Hsuan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Ting-Wen Cheng"
    },
    {
      "affs": [
        0,
        2,
        3,
        4,
        5
      ],
      "name": "Chin-Hsien Lin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ft2dc0fnc3gbb.bib",
  "cited_by": 1,
  "doi": "10.1038/s41531-026-01469-7",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737073/",
  "id": "ft2dc0fnc3gbb",
  "issns": [
    "2373-8057"
  ],
  "landing_url": "https://doi.org/10.1038/s41531-026-01469-7",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7168051115",
  "pdf_url": "https://www.nature.com/articles/s41531-026-01469-7_reference.pdf",
  "pmcid": "PMC13737073",
  "pmid": "42436138",
  "published": "2026-07-11",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/ft2dc0fnc3gbb.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:22Z",
      "native_id": "PMC13737073",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41531-026-01469-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Plasma pTau217 and pTau231 predict progression to dementia in Parkinson’s disease: a prospective longitudinal study",
  "title_text": "Plasma pTau217 and pTau231 predict progression to dementia in Parkinson’s disease: a prospective longitudinal study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:22Z",
  "url": "https://research.draconitic.com/paper/ft2dc0fnc3gbb",
  "venue": "NPJ Parkinson's Disease",
  "versions": []
}