{
  "abstract": "A 20-year-old female with asthma, Ehlers-Danlos syndrome, Hashimoto's thyroiditis, mast cell activation syndrome, and complex regional pain syndrome Type 1 (CRPS1) presented for left transfemoral amputation with osseointegration and nerve reconstruction. To limit CRPS1 exacerbation, neuraxial anesthesia with femoral and sciatic blocks was administered for analgesia. Given the reported history of convulsions following ketamine and propofol, sedation with midazolam, dexmedetomidine, and fentanyl was used. On POD 1, fascia iliaca and sciatic blocks were repeated to mitigate postoperative pain. There were no intraoperative or postoperative complications. With limited literature on anesthesia for osseointegration, this novel case highlights individualized planning, in the setting of adverse responses to anesthetic medications and challenging pain management.",
  "abstract_shown": true,
  "affiliations": [
    "College of Medicine Drexel University Philadelphia Pennsylvania USA drexel.edu.",
    "Osseointegration Limb Replacement Center Hospital for Special Surgery New York New York USA hss.edu.",
    "Department of Anesthesiology Weill Cornell Medical College New York New York USA cornell.edu.",
    "Department of Anesthesiology, Critical Care and Pain Management Hospital for Special Surgery New York New York USA hss.edu."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jake D Fanizza"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jason Shih Hoellwarth",
      "orcid": "0000-0001-7065-0656"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Uchenna O Umeh",
      "orcid": "0000-0003-4139-6702"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ft660tpmk3mzx.bib",
  "cited_by": 0,
  "doi": "10.1155/cria/6532945",
  "fulltext_url": "https://europepmc.org/articles/PMC13686131",
  "id": "ft660tpmk3mzx",
  "issns": [
    "2090-6382",
    "2090-6390"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909998",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Anesthesia and Pain Management"
    ]
  ],
  "openalex": "W7223115775",
  "pdf_url": "https://europepmc.org/articles/PMC13686131?pdf=render",
  "pmcid": "PMC13686131",
  "pmid": "42909998",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ft660tpmk3mzx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909998",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909998"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Anesthesia and Pain Management",
      "subfield": "surgery"
    }
  ],
  "title": "Anesthesia Considerations for Transfemoral Osseointegration in a Patient With CRPS, Propofol, and Ketamine Allergies: A Case Report.",
  "title_text": "Anesthesia Considerations for Transfemoral Osseointegration in a Patient With CRPS, Propofol, and Ketamine Allergies: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/ft660tpmk3mzx",
  "venue": "Case reports in anesthesiology",
  "versions": []
}