{
  "abstract": "The temporomandibular joint (TMJ) is essential for oral functions such as chewing, speaking, and swallowing. Temporomandibular disorders that impair these functions notably reduce patients' quality of life, and few therapeutic strategies are available to ameliorate these conditions. Here, we identify the neurotrophin receptor (p75NTR) as a central regulator of mandibular condylar cartilage development, mechanoadaptation, and homeostasis. p75NTR loss causes condylar and disc hypoplasia, reduced chondrocyte number, impaired load-induced anabolism, and accelerated degeneration. Conditional deletion experiments demonstrate chondrocyte-autonomous requirements for the brain-derived neurotrophic factor (BDNF)-p75NTR axis, which activates phosphoinositide 3-kinase AKT serine/threonine kinase and p38 mitogen-activated protein kinase signaling to promote proliferation and chondrogenic differentiation while restraining apoptosis. Degenerative human condyles exhibit reduced p75NTR expression levels. Together, these data establish p75NTR as a molecular hub integrating neurotrophic and mechanical cues to preserve postnatal TMJ architecture and highlight the BDNF-p75NTR axis as a potential therapeutic target.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA.",
    "Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.",
    "Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, USA.",
    "The Shapiro Family Laboratory of Viral Oncology and Aging Research, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA.",
    "Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.",
    "Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.",
    "Department of Surgery, UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.",
    "Oral and Maxillofacial Surgery, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA.",
    "Department of Growth and Development, University of Nebraska Medical Center, Omaha, NE, USA.",
    "Center for Regenerative Medicine, Steadman Philippon Research Institute, Vail, CO, USA.",
    "Department of Pediatrics, Cedars-Sinai Guerin Children’s, Los Angeles, CA, USA.",
    "Department of Orthodontics, School of Dentistry, University of Washington, Seattle, WA, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Chiho Kadota-Watanabe",
      "orcid": "0000-0003-4654-0355"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinsook Suh",
      "orcid": "0000-0002-4798-4647"
    },
    {
      "affs": [
        0
      ],
      "name": "Eric Yin",
      "orcid": "0009-0009-7549-888X"
    },
    {
      "affs": [
        0
      ],
      "name": "Byron Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Jey Kim",
      "orcid": "0009-0001-4110-1380"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "In-Won Chang"
    },
    {
      "affs": [
        4
      ],
      "name": "Sowmya Ramesh",
      "orcid": "0000-0002-4086-9603"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuna Lee",
      "orcid": "0009-0006-7704-9154"
    },
    {
      "affs": [
        0
      ],
      "name": "Joshua Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Maulik Ahuja"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Jahangiri"
    },
    {
      "affs": [
        0
      ],
      "name": "Isabelle Lao-Ngo",
      "orcid": "0009-0007-9467-0046"
    },
    {
      "affs": [
        0
      ],
      "name": "Ursula Eisinger"
    },
    {
      "affs": [
        0
      ],
      "name": "Kate Lindsey",
      "orcid": "0009-0007-4297-5374"
    },
    {
      "affs": [
        0
      ],
      "name": "Haihui Zhang",
      "orcid": "0009-0006-4619-4500"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Fatemeh Momen-Heravi",
      "orcid": "0000-0003-4534-1450"
    },
    {
      "affs": [
        6
      ],
      "name": "Juan Du"
    },
    {
      "affs": [
        6
      ],
      "name": "James M. Gardner",
      "orcid": "0000-0003-3470-9520"
    },
    {
      "affs": [
        7
      ],
      "name": "Rebeka Silva"
    },
    {
      "affs": [
        8
      ],
      "name": "Sumit Yadav"
    },
    {
      "affs": [
        2,
        9
      ],
      "name": "Chelsea S. Bahney",
      "orcid": "0000-0001-9808-8888"
    },
    {
      "affs": [
        4
      ],
      "name": "Aaron W. James",
      "orcid": "0000-0002-2002-622X"
    },
    {
      "affs": [
        3
      ],
      "name": "Reuben H. Kim"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Ophir D. Klein",
      "orcid": "0000-0002-6254-7082"
    },
    {
      "affs": [
        0,
        11
      ],
      "name": "Christine Hong",
      "orcid": "0000-0002-9123-7737"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ft7ttgqxj631x.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aef7786",
  "fulltext_url": "https://europepmc.org/articles/PMC13685922",
  "id": "ft7ttgqxj631x",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aef7786",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
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  "openalex": "W7223107283",
  "pdf_url": "https://europepmc.org/articles/PMC13685922?pdf=render",
  "pmcid": "PMC13685922",
  "pmid": "42905810",
  "published": "2026-10-21",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/ft7ttgqxj631x.ris",
  "sources": [
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      "first_seen": "2026-10-30T12:17:41Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
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  ],
  "title": "p75 NTR orchestrates chondrogenesis and mechanoadaptation to preserve temporomandibular joint development and homeostasis",
  "title_text": "p75 NTR orchestrates chondrogenesis and mechanoadaptation to preserve temporomandibular joint development and homeostasis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/ft7ttgqxj631x",
  "venue": "Science Advances",
  "versions": []
}