{
  "abstract": "Hesperidin (HES) is a natural flavonoid with antioxidant activity; however, its poor aqueous solubility and low bioavailability limit its biomedical applications. In this study, HES-loaded liposomes (HES-LPs) were prepared by thin-film hydration and incorporated into a methacrylated silk fibroin (SilMA) hydrogel to construct a photocrosslinked composite hydrogel for potential wound dressing applications. Successful methacrylation of SilMA was confirmed by ¹H nuclear magnetic resonance (¹H NMR) spectroscopy. HES-LPs exhibited a mean particle size of 87.13 ± 0.84 nm, a zeta potential of -3.80 ± 0.49 mV, an encapsulation efficiency of 72.48%, and a drug loading of 4.62%. The composite hydrogel exhibited good antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. It also exhibited sustained HES release, good cytocompatibility, and enhanced L929 fibroblast migration. Overall, the composite hydrogel represents a candidate wound-dressing platform supported by preliminary in vitro evidence.",
  "abstract_shown": true,
  "affiliations": [
    "College of Animal Sciences & Technology, Zhejiang A&F University, Hangzhou 311300, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Di Wang",
      "orcid": "0009-0002-5944-3909"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiahua Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongxia Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiyuan Bao",
      "orcid": "0000-0002-4548-0920"
    },
    {
      "affs": [
        0
      ],
      "name": "Wanfu Yue"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ftmffbxfytg5f.bib",
  "cited_by": 0,
  "doi": "10.3390/gels12100894",
  "fulltext_url": "https://europepmc.org/articles/PMC13704058",
  "id": "ftmffbxfytg5f",
  "issns": [
    "2310-2861"
  ],
  "landing_url": "https://europepmc.org/article/MED/42929928",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Silk-based biomaterials and applications"
    ]
  ],
  "openalex": "W7216187371",
  "pdf_url": "https://europepmc.org/articles/PMC13704058?pdf=render",
  "pmcid": "PMC13704058",
  "pmid": "42929928",
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ftmffbxfytg5f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929928",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929928"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Silk-based biomaterials and applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Development of a Photocrosslinked Methacrylated Silk Fibroin Hydrogel Incorporating Hesperidin-Loaded Liposomes for Wound Dressing Applications.",
  "title_text": "Development of a Photocrosslinked Methacrylated Silk Fibroin Hydrogel Incorporating Hesperidin-Loaded Liposomes for Wound Dressing Applications.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/ftmffbxfytg5f",
  "venue": "Gels (Basel, Switzerland)",
  "versions": []
}