{
  "abstract": "Peptide nucleic acids (PNAs) enable sequence-specific recognition of double-stranded DNA (dsDNA) via invasion complex formation. Here, we report a strategy using multiple parallel-stranded PNAs to enhance invasion efficiency. Cooperative binding of PNAs at adjacent target sites markedly improved invasion efficiency and enabled sequence-specific recognition of plasmid DNA under physiological conditions.",
  "abstract_shown": true,
  "affiliations": [
    "Research Center for Material Science",
    "Nagoya University",
    "Department of Chemistry, Graduate School of Science"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Masanari Shibata"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Kota Ito"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Osami Shoji"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Yuichiro Aiba",
      "orcid": "0000-0003-3994-7480"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ftwnys57x7688.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010031/v1",
  "fulltext_url": null,
  "id": "ftwnys57x7688",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010031/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|DNA and Nucleic Acid Chemistry"
    ]
  ],
  "openalex": "W7220863194",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010031/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/ftwnys57x7688.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15010031",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010031/v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|DNA and Nucleic Acid Chemistry",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Enhancing double-duplex invasion by using multiple parallel-stranded peptide nucleic acids",
  "title_text": "Enhancing double-duplex invasion by using multiple parallel-stranded peptide nucleic acids",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/ftwnys57x7688",
  "venue": "ChemRxiv",
  "versions": []
}