{
  "abstract": "Metal-based photoCORMs (Photoactivatable carbon monoxide-releasing molecules) have traditionally relied on photolabile M–CO bonds, constraining modular design and limiting opportunities for integrating additional functions. Here we report a modular metalbased platform in which CO generation is encoded within a photolabile carbamate rather than a M–CO bond, enabling visible-light-controlled, spatiotemporal CO release while preserving the synthetic flexibility to integrate multimodal functions within a single molecular architecture. As a proof of concept, we constructed a fluorogenic, CA-IX-targeted Pt(IV) complex in which a naphthalimide chromophore is coupled to the metal centre through a carbamate CO-releasing module. Photoexcitation of the chromophore initiates a programmed cascade comprising carbamate scission for CO release along with fluorogenic activation of the CA-IX-inhibiting dye, and reduction of Pt(IV) to cytotoxic Pt(II), validating the modular design. More broadly, this work demonstrates that carbamate photolysis provides a broadly applicable route to programmable, stimuli-controlled CO release, independent of metal–carbonyl chemistry, integrated with modular multifunctional therapeutic architectures.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Rakesh Halder"
    },
    {
      "name": "Shamik Chanda"
    },
    {
      "name": "Manisha Rathore"
    },
    {
      "name": "Sayar Ghosh"
    },
    {
      "name": "Joshua Stephen Kingsley"
    },
    {
      "name": "Simone Giovannuzzi"
    },
    {
      "name": "Subhendu Karmakar"
    },
    {
      "name": "Goutam Sahoo"
    },
    {
      "name": "Shilpendu Ghosh"
    },
    {
      "name": "Gendan Lal"
    },
    {
      "name": "Aniruddha Das"
    },
    {
      "name": "Claudiu T Supuran"
    },
    {
      "name": "Rajdeep Guha"
    },
    {
      "name": "Rahul Das"
    },
    {
      "name": "Sandeep Singh"
    },
    {
      "name": "Sangita Sen"
    },
    {
      "name": "Arindam Mukherjee",
      "orcid": "0000-0001-9545-8628"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ftxch49hdhsnx.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008336/v1",
  "fulltext_url": null,
  "id": "ftxch49hdhsnx",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008336/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Metal complexes synthesis and properties"
    ]
  ],
  "openalex": "W7208770273",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008336/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-04",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/ftxch49hdhsnx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008336",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008336/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Metal complexes synthesis and properties",
      "subfield": "oncology"
    }
  ],
  "title": "Photochemical Carbamate Scission Redefines Metal-Based PhotoCORMs through Multi-Output Activation",
  "title_text": "Photochemical Carbamate Scission Redefines Metal-Based PhotoCORMs through Multi-Output Activation",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/ftxch49hdhsnx",
  "venue": "ChemRxiv",
  "versions": []
}