{
  "abstract": "Introduction: Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in adults with moderate-to-severe Malassezia folliculitis.\n\nMethods: In this 12-week, multicenter, single-arm trial, adults with moderate-to-severe (grade 2–3) MF received weekly 30% SSA peeling for 8 weeks combined with once-daily topical SAZ application. The primary end point was the overall efficacy rate at week 8 in the full analysis set (FAS), based on skin lesion reduction and Malassezia microscopy. Secondary end points included symptom response rates (pruritus, scaling, erythema, greasiness), recurrence rate, patient satisfaction, and quality-of-life (QoL) outcomes.\n\nResults: The overall efficacy rate at week 8 was 95.42% (95% confidence interval [CI] 91.95–97.69%) in the FAS (n = 240) and 99.52% (95% CI 97.35–99.99%) in the per-protocol set (PPS; n = 212). Clinically meaningful improvements were observed from week 2 (69.17%). By week 8, erythema (94.76%), greasiness (95.24%), pruritus (90.95%), and scaling (86.67%) had all responded. During the 4-week post-treatment follow-up, recurrence was observed in 2 of 237 patients included in the FAS recurrence analysis (0.84%). Treatment-related adverse events (AEs) occurred in 2.92% of patients and were all mild-to-moderate; no serious AEs were reported.\n\nConclusions: In this multicenter, single-arm study, the combined regimen was associated with clinically relevant improvement and was generally well tolerated in adults with moderate-to-severe MF. These encouraging findings support further evaluation in controlled studies with longer follow-up.\n\nTrial registration: MR-44-22-009680.",
  "abstract_shown": true,
  "affiliations": [
    "Laser and Dermatology Surgery Center, Dermatology Hospital of Southern Medical University, No. 2 Lujing Road, Yuexiu District, Guangzhou, 510091 China",
    "The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China",
    "Guangzhou Institute of Dermatology, Guangzhou, China",
    "Shenzhen Hospital of Southern Medical University, Shenzhen, China",
    "Shanghai Skin Disease Hospital, Shanghai, China",
    "The First Hospital of Jilin University, Changchun, China",
    "The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China",
    "The First Affiliated Hospital of Zhejiang University, Hangzhou, China",
    "Chengdu Second People’s Hospital, Chengdu, China",
    "Xuhui District Central Hospital, Shanghai, China",
    "Shanghai Tongren Hospital, Shanghai, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuanzhi Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinjin Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Wei Lai"
    },
    {
      "affs": [
        2
      ],
      "name": "Xingdong Ye"
    },
    {
      "affs": [
        3
      ],
      "name": "Yanhua Liang"
    },
    {
      "affs": [
        4
      ],
      "name": "Xiuli Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Shanshan Li"
    },
    {
      "affs": [
        6
      ],
      "name": "Weihui Zeng"
    },
    {
      "affs": [
        7
      ],
      "name": "Hong Fang"
    },
    {
      "affs": [
        8
      ],
      "name": "Qingbiao Wa"
    },
    {
      "affs": [
        9
      ],
      "name": "Xiujuan Wu"
    },
    {
      "affs": [
        10
      ],
      "name": "Ningjing Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Bin Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhenfeng Liu",
      "orcid": "0000-0002-5968-2750"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ftxvb4dc14e10.bib",
  "cited_by": 0,
  "doi": "10.1007/s13555-026-01915-7",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696610/",
  "id": "ftxvb4dc14e10",
  "issns": [
    "2193-8210",
    "2190-9172"
  ],
  "landing_url": "https://doi.org/10.1007/s13555-026-01915-7",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "lcc",
      "RL1-803"
    ],
    [
      "openalex",
      "2713|Nail Diseases and Treatments"
    ]
  ],
  "openalex": "W7214158692",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s13555-026-01915-7.pdf",
  "pmcid": "PMC13696610",
  "pmid": "42782503",
  "published": "2026-09-01",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/ftxvb4dc14e10.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "PMC13696610",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s13555-026-01915-7"
    },
    {
      "first_seen": "2026-10-30T13:45:32Z",
      "native_id": "1ed6abe3b4c84bcb8afc1a924c78056a",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s13555-026-01915-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Nail Diseases and Treatments",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial",
  "title_text": "Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:32Z",
  "url": "https://research.draconitic.com/paper/ftxvb4dc14e10",
  "venue": "Dermatology and Therapy",
  "versions": []
}