{
  "abstract": "Regulated cell death (RCD) is characterized by distinct molecular execution mechanisms, but its initiation, progression, and biological consequences are increasingly recognized as being shaped by cellular metabolism. Bioenergetic state, redox homeostasis, nutrient availability, metal ion metabolism, inflammatory metabolism, and organelle function collectively determine cellular susceptibility to death and influence the activation and execution of diverse RCD programs. In this review, we synthesize the metabolic hallmarks of established, independently validated, and recently proposed forms of RCD, highlighting both their mechanistic diversity and their extensive metabolic convergence. We then examine the endogenous mechanisms that maintain metabolic homeostasis and discuss how their disruption reshapes cell death responses in human disease and therapeutic contexts. Together, these insights provide a guide to the metabolic landscape of RCD and reveal metabolism not only as a modifier of cell death, but as a fundamental determinant of when, how, and with what consequences cells die. We conclude by discussing key conceptual and mechanistic challenges and emerging opportunities for therapeutically exploiting the metabolic control of RCD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, UT Southwestern Medical Center, Dallas, Texas USA",
    "Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China",
    "Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China",
    "Centre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Université, Inserm, Paris, France",
    "Institut Gustave Roussy, Université Paris-Saclay, INSERM US23/CNRS UAR 3655, Metabolomics and Cell Biology Platforms, UMS AMMICa, Villejuif Cedex, France",
    "Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges-Pompidou, AP-HP, Paris, France",
    "Centre de Recherche des Cordeliers, Équipe labellisée par la Ligue contre le cancer, Paris, France"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rui Kang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Xin Chen",
      "orcid": "0000-0003-3668-4830"
    },
    {
      "affs": [
        3,
        4,
        5,
        6
      ],
      "name": "Guido Kroemer",
      "orcid": "0000-0002-9334-4405"
    },
    {
      "affs": [
        0
      ],
      "name": "Daolin Tang",
      "orcid": "0000-0002-1903-6180"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fv8h9gqff8c9b.bib",
  "cited_by": 0,
  "doi": "10.1038/s41422-026-01306-9",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737170/",
  "id": "fv8h9gqff8c9b",
  "issns": [
    "1001-0602",
    "1748-7838"
  ],
  "landing_url": "https://doi.org/10.1038/s41422-026-01306-9",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "1312|Cell death mechanisms and regulation"
    ]
  ],
  "openalex": "W7222933928",
  "pdf_url": "https://www.nature.com/articles/s41422-026-01306-9.pdf",
  "pmcid": "PMC13737170",
  "pmid": "42897232",
  "published": "2026-10-20",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/fv8h9gqff8c9b.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:27Z",
      "native_id": "PMC13737170",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41422-026-01306-9"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Cell death mechanisms and regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Metabolic hallmarks of regulated cell death",
  "title_text": "Metabolic hallmarks of regulated cell death",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:27Z",
  "url": "https://research.draconitic.com/paper/fv8h9gqff8c9b",
  "venue": "Cell Research",
  "versions": []
}