{
  "abstract": "This study demonstrates guest-directed crystallization of zeolitic imidazolate framework-8 (ZIF-8) on carboxylated cotton, using eugenol as both a fragrance guest and a crystallization modulator to achieve pH-responsive release under mildly acidic, perspiration-like conditions. Particular emphasis is placed on how the timing of eugenol introduction modulates competitive guest-linker interactions during ZIF-8 crystallization, thereby governing guest retention and pH-responsive release. During a 72 h three-step cumulative synthesis, eugenol was introduced either at the onset of ZIF-8 growth or after 48 h to regulate crystal formation, guest-binding state, and subsequent release behavior. Spectroscopic analyses and density functional theory calculations revealed coordination between the phenolic oxygen of eugenol and Zn sites, providing molecular-level evidence for guest-ZIF-8 interactions. Early-stage addition suppressed ZIF-8 nucleation, producing larger crystals and increasing the fraction of framework-coordinated eugenol. Consequently, eugenol release became more strongly pH-responsive because coordinated eugenol was preferentially released upon acid-induced framework degradation. In contrast, introducing eugenol after 48 h led to mostly physical retention within the framework, resulting in diffusion-controlled release with substantially weaker pH dependence. The eugenol-containing ZIF-8 fabrics also exhibited strong antibacterial activity against Escherichia coli through the combined effects of ZIF-8 and eugenol. These findings establish guest-addition timing as an effective synthetic parameter for regulating metal-organic framework crystallization, guest-binding state, and stimulus-responsive release behavior.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Fashion and Textiles, Seoul National University, Seoul08826, Republic of Korea.",
    "Department of Mechanical and Automotive Engineering, Kongju National University, Cheonan31080, Republic of Korea.",
    "Department of Future Convergence Engineering, Kongju National University, Cheonan31080, Republic of Korea.",
    "Research Institute of Human Ecology, Seoul National University, Seoul08826, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Juyeon Baek",
      "orcid": "0009-0000-1994-9468"
    },
    {
      "affs": [
        0
      ],
      "name": "Ye-Eun Woo",
      "orcid": "0009-0002-4338-5388"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jung-Hoon Yun"
    },
    {
      "affs": [
        2
      ],
      "name": "Gyeong Chan Kim"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Jooyoun Kim",
      "orcid": "0000-0001-5043-9378"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fv8s7qv5g1j4s.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.langmuir.6c05056",
  "fulltext_url": "https://europepmc.org/articles/PMC13648272",
  "id": "fv8s7qv5g1j4s",
  "issns": [
    "0743-7463",
    "1520-5827"
  ],
  "landing_url": "https://europepmc.org/article/MED/42917693",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Metal-Organic Frameworks: Synthesis and Applications"
    ]
  ],
  "openalex": "W7214325141",
  "pdf_url": "https://europepmc.org/articles/PMC13648272?pdf=render",
  "pmcid": "PMC13648272",
  "pmid": "42917693",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fv8s7qv5g1j4s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42917693",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42917693"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Metal-Organic Frameworks: Synthesis and Applications",
      "subfield": "inorganic"
    }
  ],
  "title": "Guest-Directed Crystallization of ZIF-8 Regulates Eugenol Binding and pH-Responsive Release.",
  "title_text": "Guest-Directed Crystallization of ZIF-8 Regulates Eugenol Binding and pH-Responsive Release.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/fv8s7qv5g1j4s",
  "venue": "Langmuir : the ACS journal of surfaces and colloids",
  "versions": []
}